Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 353156..353694 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF71_RS15140 Protein ID WP_000802136.1
Coordinates 353156..353455 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF71_RS15145 Protein ID WP_001107719.1
Coordinates 353452..353694 (-) Length 81 a.a.

Genomic Context

GTF71_RS15100GTF71_RS15105GTF71_RS15110GTF71_RS15115GTF71_RS15120GTF71_RS15125GTF71_RS15130GTF71_RS15135GTF71_RS15150GTF71_RS15155GTF71_RS15160GTF71_RS15165GTF71_RS15170GTF71_RS15175GTF71_RS15180GTF71_RS15140GTF71_RS15145
Location: 349091..349273 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 349473..349946 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 349943..350053 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 350095..350721 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 350844..351542 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 351546..351662 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 352240..352419 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 352633..353028 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 353923..354501 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 354505..354615 (111 bp)
Type: Others
Protein ID: WP_071908313.1
Location: 355039..355722 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 355936..356202 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 356357..356956 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 357237..358172 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 358138..358278 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 353156..353455 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 353452..353694 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15100349091..349273+183WP_000923182.1DUF645 family protein-
GTF71_RS15105349473..349946+474WP_001161076.1GrpB family protein-
GTF71_RS15110349943..350053+111WP_071908312.1DUF3265 domain-containing protein-
GTF71_RS15115350095..350721+627WP_000365424.1LysE family translocator-
GTF71_RS15120350844..351542+699WP_001890502.1hypothetical protein-
GTF71_RS15125351546..351662+117WP_071908339.1DUF3265 domain-containing protein-
GTF71_RS15130352240..352419+180WP_001883058.1DUF645 family protein-
GTF71_RS15135352633..353028+396WP_000870857.1DUF3465 domain-containing protein-
GTF71_RS15140353156..353455-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF71_RS15145353452..353694-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
GTF71_RS15150353923..354501+579WP_000110120.1hypothetical protein-
GTF71_RS15155354505..354615+111WP_071908313.1DUF3265 domain-containing protein-
GTF71_RS15160355039..355722+684WP_000877436.1hypothetical protein-
GTF71_RS15165355936..356202+267WP_000937852.1hypothetical protein-
GTF71_RS15170356357..356956+600WP_000429495.1hypothetical protein-
GTF71_RS15175357237..358172+936WP_000051985.1restriction endonuclease-
GTF71_RS15180358138..358278+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145848 WP_000802136.1 NZ_CP047300:c353455-353156 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145848 NZ_CP062702:3475962-3476249 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145848 WP_001107719.1 NZ_CP047300:c353694-353452 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145848 NZ_CP062702:3475771-3475962 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References