145848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 353156..353694 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF71_RS15140 Protein ID WP_000802136.1
Coordinates 353156..353455 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF71_RS15145 Protein ID WP_001107719.1
Coordinates 353452..353694 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF71_RS15100 349091..349273 + 183 WP_000923182.1 DUF645 family protein -
GTF71_RS15105 349473..349946 + 474 WP_001161076.1 GrpB family protein -
GTF71_RS15110 349943..350053 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF71_RS15115 350095..350721 + 627 WP_000365424.1 LysE family translocator -
GTF71_RS15120 350844..351542 + 699 WP_001890502.1 hypothetical protein -
GTF71_RS15125 351546..351662 + 117 WP_071908339.1 DUF3265 domain-containing protein -
GTF71_RS15130 352240..352419 + 180 WP_001883058.1 DUF645 family protein -
GTF71_RS15135 352633..353028 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GTF71_RS15140 353156..353455 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF71_RS15145 353452..353694 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GTF71_RS15150 353923..354501 + 579 WP_000110120.1 hypothetical protein -
GTF71_RS15155 354505..354615 + 111 WP_071908313.1 DUF3265 domain-containing protein -
GTF71_RS15160 355039..355722 + 684 WP_000877436.1 hypothetical protein -
GTF71_RS15165 355936..356202 + 267 WP_000937852.1 hypothetical protein -
GTF71_RS15170 356357..356956 + 600 WP_000429495.1 hypothetical protein -
GTF71_RS15175 357237..358172 + 936 WP_000051985.1 restriction endonuclease -
GTF71_RS15180 358138..358278 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306926..439292 132366
inside Integron - - 312006..438916 126910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145848 WP_000802136.1 NZ_CP047300:c353455-353156 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145848 NZ_CP062702:3475962-3476249 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145848 WP_001107719.1 NZ_CP047300:c353694-353452 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145848 NZ_CP062702:3475771-3475962 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References