145870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365251..365829 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF75_RS15700 Protein ID WP_001180243.1
Coordinates 365251..365568 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF75_RS15705 Protein ID WP_000557292.1
Coordinates 365587..365829 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15655 360442..360837 + 396 WP_000046952.1 hypothetical protein -
GTF75_RS15660 361140..361321 + 182 Protein_351 DUF645 family protein -
GTF75_RS15665 361498..361893 + 396 WP_000046953.1 hypothetical protein -
GTF75_RS15670 362037..362573 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GTF75_RS15675 362870..363049 + 180 WP_001883039.1 DUF645 family protein -
GTF75_RS15680 363245..363670 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GTF75_RS15685 363819..364166 + 348 WP_000933409.1 hypothetical protein -
GTF75_RS15690 364313..364606 + 294 WP_125460920.1 hypothetical protein -
GTF75_RS15695 364962..365057 + 96 WP_001907607.1 DUF645 family protein -
GTF75_RS15700 365251..365568 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF75_RS15705 365587..365829 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF75_RS15710 366071..366580 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GTF75_RS15715 366637..367290 + 654 WP_000226874.1 hypothetical protein -
GTF75_RS15720 367600..367818 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GTF75_RS15725 368221..368454 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GTF75_RS15730 368879..369059 + 181 Protein_365 DUF645 family protein -
GTF75_RS15735 369326..369613 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF75_RS15740 369624..369941 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GTF75_RS15745 369938..370048 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF75_RS15750 370225..370350 + 126 WP_001944767.1 DUF645 family protein -
GTF75_RS15755 370366..370404 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145870 WP_001180243.1 NZ_CP047302:c365568-365251 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145870 NZ_CP062705:1094580-1094915 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145870 WP_000557292.1 NZ_CP047302:c365829-365587 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145870 NZ_CP062705:1094332-1094580 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References