Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365251..365829 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF75_RS15700 Protein ID WP_001180243.1
Coordinates 365251..365568 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF75_RS15705 Protein ID WP_000557292.1
Coordinates 365587..365829 (-) Length 81 a.a.

Genomic Context

GTF75_RS15655GTF75_RS15660GTF75_RS15665GTF75_RS15670GTF75_RS15675GTF75_RS15680GTF75_RS15685GTF75_RS15690GTF75_RS15695GTF75_RS15710GTF75_RS15715GTF75_RS15720GTF75_RS15725GTF75_RS15730GTF75_RS15735GTF75_RS15740GTF75_RS15745GTF75_RS15750GTF75_RS15755GTF75_RS15700GTF75_RS15705
Location: 360442..360837 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 361140..361321 (182 bp)
Type: Others
Protein ID: Protein_351
Location: 361498..361893 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 362037..362573 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 362870..363049 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 363245..363670 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 363819..364166 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 364313..364606 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 364962..365057 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366071..366580 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 366637..367290 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 367600..367818 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368221..368454 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 368879..369059 (181 bp)
Type: Others
Protein ID: Protein_365
Location: 369326..369613 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 369624..369941 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 369938..370048 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370225..370350 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370366..370404 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 365251..365568 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 365587..365829 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS15655360442..360837+396WP_000046952.1hypothetical protein-
GTF75_RS15660361140..361321+182Protein_351DUF645 family protein-
GTF75_RS15665361498..361893+396WP_000046953.1hypothetical protein-
GTF75_RS15670362037..362573+537WP_000644491.1nucleotidyltransferase family protein-
GTF75_RS15675362870..363049+180WP_001883039.1DUF645 family protein-
GTF75_RS15680363245..363670+426WP_000403014.1GNAT family N-acetyltransferase-
GTF75_RS15685363819..364166+348WP_000933409.1hypothetical protein-
GTF75_RS15690364313..364606+294WP_125460920.1hypothetical protein-
GTF75_RS15695364962..365057+96WP_001907607.1DUF645 family protein-
GTF75_RS15700365251..365568-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF75_RS15705365587..365829-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF75_RS15710366071..366580+510WP_000405987.1GNAT family N-acetyltransferase-
GTF75_RS15715366637..367290+654WP_000226874.1hypothetical protein-
GTF75_RS15720367600..367818+219WP_001917086.1DUF3709 domain-containing protein-
GTF75_RS15725368221..368454+234WP_032482776.1DUF3709 domain-containing protein-
GTF75_RS15730368879..369059+181Protein_365DUF645 family protein-
GTF75_RS15735369326..369613+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF75_RS15740369624..369941+318WP_001232701.1HigA family addiction module antidote protein-
GTF75_RS15745369938..370048+111WP_134814058.1DUF3265 domain-containing protein-
GTF75_RS15750370225..370350+126WP_001944767.1DUF645 family protein-
GTF75_RS15755370366..370404+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145870 WP_001180243.1 NZ_CP047302:c365568-365251 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145870 NZ_CP062705:1094580-1094915 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145870 WP_000557292.1 NZ_CP047302:c365829-365587 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145870 NZ_CP062705:1094332-1094580 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References