Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 53014..53554 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag C4E16_RS14450 Protein ID WP_000277238.1
Coordinates 53014..53283 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag C4E16_RS14455 Protein ID WP_001258569.1
Coordinates 53276..53554 (-) Length 93 a.a.

Genomic Context

C4E16_RS14390C4E16_RS14395C4E16_RS14400C4E16_RS14415C4E16_RS14420C4E16_RS14435C4E16_RS19415C4E16_RS14445C4E16_RS14465C4E16_RS19420C4E16_RS14470C4E16_RS14475C4E16_RS14480C4E16_RS14485C4E16_RS14490C4E16_RS14495C4E16_RS19550C4E16_RS19555C4E16_RS14515C4E16_RS14385C4E16_RS14425C4E16_RS14430C4E16_RS14450C4E16_RS14455
Location: 48504..48890 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 48947..49060 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49009..49290 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 49548..50084 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50221..50736 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52045..52170 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52186..52224 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52420..52866 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 53840..54118 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 54370..54576 (207 bp)
Type: Others
Protein ID: Protein_68
Location: 54776..54877 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 54867..55253 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 55448..55699 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 55672..55821 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 55913..56155 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 56407..56685 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 57060..57203 (144 bp)
Type: Others
Protein ID: Protein_75
Location: 57257..57295 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 57507..57974 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 48018..48260 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 50886..51383 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 51380..51652 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 53014..53283 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 53276..53554 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1438548018..48260-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C4E16_RS1439048504..48890+387WP_001015867.1NUDIX hydrolase-
C4E16_RS1439548947..49060+114WP_001900214.1hypothetical protein-
C4E16_RS1440049009..49290+282WP_001894429.1DUF1289 domain-containing protein-
C4E16_RS1441549548..50084+537WP_000469482.1GNAT family N-acetyltransferase-
C4E16_RS1442050221..50736+516WP_001201509.1lipocalin family protein-
C4E16_RS1442550886..51383-498WP_000982260.1GNAT family N-acetyltransferase-
C4E16_RS1443051380..51652-273WP_000246253.1DUF1778 domain-containing protein-
C4E16_RS1443552045..52170+126WP_001900195.1DUF645 family protein-
C4E16_RS1941552186..52224+39WP_106019118.1hypothetical protein-
C4E16_RS1444552420..52866+447WP_000006157.1hypothetical protein-
C4E16_RS1445053014..53283-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
C4E16_RS1445553276..53554-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C4E16_RS1446553840..54118+279WP_001921601.1DUF3709 domain-containing protein-
C4E16_RS1942054370..54576+207Protein_68DUF3709 domain-containing protein-
C4E16_RS1447054776..54877+102WP_001921603.1hypothetical protein-
C4E16_RS1447554867..55253+387WP_000703163.1VOC family protein-
C4E16_RS1448055448..55699+252WP_001890111.1TIGR03643 family protein-
C4E16_RS1448555672..55821+150WP_071908333.1DUF3265 domain-containing protein-
C4E16_RS1449055913..56155+243WP_000107461.1hypothetical protein-
C4E16_RS1449556407..56685+279WP_000280324.1DUF3709 domain-containing protein-
C4E16_RS1955057060..57203+144Protein_75DUF645 family protein-
C4E16_RS1955557257..57295+39WP_082798268.1hypothetical protein-
C4E16_RS1451557507..57974+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T95377 WP_000277238.1 NZ_CP026648:c53283-53014 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T95377 NZ_CP026648:c53283-53014 [Vibrio cholerae O1 biovar El Tor]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT95377 WP_001258569.1 NZ_CP026648:c53554-53276 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT95377 NZ_CP026648:c53554-53276 [Vibrio cholerae O1 biovar El Tor]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References