87020

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 341423..341982 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag CSW01_RS15860 Protein ID WP_000578476.1
Coordinates 341423..341701 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag CSW01_RS15865 Protein ID WP_000381183.1
Coordinates 341698..341982 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS15805 336501..337007 + 507 WP_000393074.1 hypothetical protein -
CSW01_RS15810 337164..337550 + 387 WP_000703163.1 VOC family protein -
CSW01_RS15815 337807..338010 + 204 WP_001911580.1 hypothetical protein -
CSW01_RS15825 338205..338456 + 252 WP_001890111.1 TIGR03643 family protein -
CSW01_RS15830 338429..338578 + 150 WP_071908333.1 DUF3265 domain-containing protein -
CSW01_RS15835 338725..339150 + 426 WP_000415750.1 hypothetical protein -
CSW01_RS15840 339356..339979 + 624 WP_000247070.1 DUF1349 domain-containing protein -
CSW01_RS15845 340192..340671 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
CSW01_RS15855 340859..341272 + 414 WP_000049420.1 VOC family protein -
CSW01_RS15860 341423..341701 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CSW01_RS15865 341698..341982 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSW01_RS15870 342177..342692 + 516 WP_001201520.1 lipocalin family protein -
CSW01_RS15875 342757..343353 + 597 WP_000255434.1 hypothetical protein -
CSW01_RS15885 343744..343926 + 183 WP_000923182.1 DUF645 family protein -
CSW01_RS15890 344126..344599 + 474 WP_001161076.1 GrpB family protein -
CSW01_RS15895 344614..344706 + 93 WP_014378730.1 DUF3265 domain-containing protein -
CSW01_RS15900 344748..345374 + 627 WP_000365424.1 LysE family translocator -
CSW01_RS15905 345497..346195 + 699 WP_001890502.1 hypothetical protein -
CSW01_RS15910 346205..346315 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T87020 WP_000578476.1 NZ_CP024163:c341701-341423 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T87020 NZ_CP024163:c341701-341423 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT87020 WP_000381183.1 NZ_CP024163:c341982-341698 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT87020 NZ_CP024163:c341982-341698 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References