Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 341423..341982 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag CSW01_RS15860 Protein ID WP_000578476.1
Coordinates 341423..341701 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag CSW01_RS15865 Protein ID WP_000381183.1
Coordinates 341698..341982 (-) Length 95 a.a.

Genomic Context

CSW01_RS15805CSW01_RS15810CSW01_RS15815CSW01_RS15825CSW01_RS15830CSW01_RS15835CSW01_RS15840CSW01_RS15845CSW01_RS15855CSW01_RS15870CSW01_RS15875CSW01_RS15885CSW01_RS15890CSW01_RS15895CSW01_RS15900CSW01_RS15905CSW01_RS15910CSW01_RS15860CSW01_RS15865
Location: 336501..337007 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337164..337550 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 337807..338010 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 338205..338456 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 338429..338578 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 338725..339150 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 339356..339979 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 340192..340671 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 340859..341272 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 342177..342692 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 342757..343353 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 343744..343926 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 344126..344599 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 344614..344706 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 344748..345374 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 345497..346195 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 346205..346315 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 341423..341701 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 341698..341982 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS15805336501..337007+507WP_000393074.1hypothetical protein-
CSW01_RS15810337164..337550+387WP_000703163.1VOC family protein-
CSW01_RS15815337807..338010+204WP_001911580.1hypothetical protein-
CSW01_RS15825338205..338456+252WP_001890111.1TIGR03643 family protein-
CSW01_RS15830338429..338578+150WP_071908333.1DUF3265 domain-containing protein-
CSW01_RS15835338725..339150+426WP_000415750.1hypothetical protein-
CSW01_RS15840339356..339979+624WP_000247070.1DUF1349 domain-containing protein-
CSW01_RS15845340192..340671+480WP_000009888.1lecithin retinol acyltransferase family protein-
CSW01_RS15855340859..341272+414WP_000049420.1VOC family protein-
CSW01_RS15860341423..341701-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
CSW01_RS15865341698..341982-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
CSW01_RS15870342177..342692+516WP_001201520.1lipocalin family protein-
CSW01_RS15875342757..343353+597WP_000255434.1hypothetical protein-
CSW01_RS15885343744..343926+183WP_000923182.1DUF645 family protein-
CSW01_RS15890344126..344599+474WP_001161076.1GrpB family protein-
CSW01_RS15895344614..344706+93WP_014378730.1DUF3265 domain-containing protein-
CSW01_RS15900344748..345374+627WP_000365424.1LysE family translocator-
CSW01_RS15905345497..346195+699WP_001890502.1hypothetical protein-
CSW01_RS15910346205..346315+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T87020 WP_000578476.1 NZ_CP024163:c341701-341423 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T87020 NZ_CP024163:c341701-341423 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT87020 WP_000381183.1 NZ_CP024163:c341982-341698 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT87020 NZ_CP024163:c341982-341698 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References