Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 406416..407200 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag N900_RS16125 Protein ID WP_001114075.1
Coordinates 406416..406685 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag N900_RS16130 Protein ID WP_000921691.1
Coordinates 406679..407200 (+) Length 174 a.a.

Genomic Context

N900_RS16090N900_RS16095N900_RS16100N900_RS16105N900_RS16110N900_RS16115N900_RS16120N900_RS20070N900_RS16125N900_RS16130N900_RS20075N900_RS16135N900_RS16150N900_RS16155N900_RS16165N900_RS16140N900_RS16145
Location: 401783..402699 (917 bp)
Type: Others
Protein ID: Protein_421
Location: 402856..403245 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403381..403590 (210 bp)
Type: Others
Protein ID: Protein_423
Location: 403709..404146 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 404210..404428 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404603..405475 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405625..406224 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406281..406385 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 406416..406685 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 406679..407200 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 407499..407624 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 407875..408270 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 409161..409676 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 409860..410273 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 410828..412004 (1177 bp)
Type: Others
Protein ID: Protein_437
Location: 408409..408687 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 408684..408968 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS16090401783..402699+917Protein_421alpha/beta hydrolase-
N900_RS16095402856..403245+390WP_001081302.1hypothetical protein-
N900_RS16100403381..403590+210Protein_423GNAT family N-acetyltransferase-
N900_RS16105403709..404146+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N900_RS16110404210..404428+219WP_071908318.1GNAT family N-acetyltransferase-
N900_RS16115404603..405475+873WP_000254716.1DUF3800 domain-containing protein-
N900_RS16120405625..406224+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
N900_RS20070406281..406385+105WP_099607150.1acetyltransferase-
N900_RS16125406416..406685+270WP_001114075.1DUF4160 domain-containing proteinToxin
N900_RS16130406679..407200+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
N900_RS20075407499..407624+126WP_001905700.1DUF645 family protein-
N900_RS16135407875..408270+396WP_001000867.1hypothetical protein-
N900_RS16140408409..408687-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
N900_RS16145408684..408968-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
N900_RS16150409161..409676+516WP_000343779.1GNAT family N-acetyltransferase-
N900_RS16155409860..410273+414WP_000049420.1VOC family protein-
N900_RS16165410828..412004+1177Protein_437IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035
flankIS/Tn--403709..404146437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T45818 WP_001114075.1 NZ_CP006948:406416-406685 [Vibrio cholerae O1 str. KW3]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T45818 NZ_CP006948:406416-406685 [Vibrio cholerae O1 str. KW3]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT45818 WP_000921691.1 NZ_CP006948:406679-407200 [Vibrio cholerae O1 str. KW3]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT45818 NZ_CP006948:406679-407200 [Vibrio cholerae O1 str. KW3]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References