145897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 425458..426413 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GTF74_RS16105 Protein ID WP_000118351.1
Coordinates 425880..426413 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GTF74_RS16100 Protein ID WP_001882332.1
Coordinates 425458..425883 (+) Length 142 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS16055 420988..421239 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF74_RS16060 421229..421516 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF74_RS16065 421644..422099 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF74_RS16070 422421..422573 + 153 WP_001884520.1 DUF645 family protein -
GTF74_RS16075 422775..423272 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF74_RS16080 423269..423541 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF74_RS16085 423772..424440 + 669 WP_000043871.1 hypothetical protein -
GTF74_RS16090 424592..424879 + 288 WP_000426470.1 hypothetical protein -
GTF74_RS16095 425020..425391 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF74_RS16100 425458..425883 + 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin
GTF74_RS16105 425880..426413 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
GTF74_RS16110 426615..426872 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF74_RS16115 426860..427162 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF74_RS16120 427396..428313 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF74_RS16125 428470..428859 + 390 WP_001081302.1 hypothetical protein -
GTF74_RS16130 428995..429204 + 210 Protein_472 GNAT family N-acetyltransferase -
GTF74_RS16135 429323..429760 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF74_RS16140 429824..430042 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF74_RS16145 430217..431089 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263
flank IS/Tn - - 429323..429760 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(97-153)

Antitoxin

(57-133)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T145897 WP_000118351.1 NZ_CP047304:425880-426413 [Vibrio cholerae O1 biovar El Tor]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T145897 NZ_CP062708:c458523-458038 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT145897 WP_001882332.1 NZ_CP047304:425458-425883 [Vibrio cholerae O1 biovar El Tor]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT145897 NZ_CP062708:c458792-458514 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q9KM94


Antitoxin

Source ID Structure

References