Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 425458..426413 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GTF74_RS16105 Protein ID WP_000118351.1
Coordinates 425880..426413 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GTF74_RS16100 Protein ID WP_001882332.1
Coordinates 425458..425883 (+) Length 142 a.a.

Genomic Context

GTF74_RS16055GTF74_RS16060GTF74_RS16065GTF74_RS16070GTF74_RS16085GTF74_RS16090GTF74_RS16095GTF74_RS16100GTF74_RS16105GTF74_RS16110GTF74_RS16115GTF74_RS16120GTF74_RS16125GTF74_RS16130GTF74_RS16135GTF74_RS16140GTF74_RS16145GTF74_RS16075GTF74_RS16080
Location: 420988..421239 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 421229..421516 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421644..422099 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 422421..422573 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423772..424440 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424592..424879 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 425020..425391 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 425458..425883 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 425880..426413 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 426615..426872 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426860..427162 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 427396..428313 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 428470..428859 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428995..429204 (210 bp)
Type: Others
Protein ID: Protein_472
Location: 429323..429760 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429824..430042 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 430217..431089 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 422775..423272 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 423269..423541 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS16055420988..421239+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS16060421229..421516+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF74_RS16065421644..422099+456WP_001245327.1GNAT family N-acetyltransferase-
GTF74_RS16070422421..422573+153WP_001884520.1DUF645 family protein-
GTF74_RS16075422775..423272-498WP_000982260.1GNAT family N-acetyltransferase-
GTF74_RS16080423269..423541-273WP_000246253.1DUF1778 domain-containing protein-
GTF74_RS16085423772..424440+669WP_000043871.1hypothetical protein-
GTF74_RS16090424592..424879+288WP_000426470.1hypothetical protein-
GTF74_RS16095425020..425391+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF74_RS16100425458..425883+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
GTF74_RS16105425880..426413+534WP_000118351.1GNAT family N-acetyltransferaseToxin
GTF74_RS16110426615..426872+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS16115426860..427162+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF74_RS16120427396..428313+918WP_000186333.1alpha/beta hydrolase-
GTF74_RS16125428470..428859+390WP_001081302.1hypothetical protein-
GTF74_RS16130428995..429204+210Protein_472GNAT family N-acetyltransferase-
GTF74_RS16135429323..429760+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF74_RS16140429824..430042+219WP_071908318.1GNAT family N-acetyltransferase-
GTF74_RS16145430217..431089+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263
flankIS/Tn--429323..429760437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T145897 WP_000118351.1 NZ_CP047304:425880-426413 [Vibrio cholerae O1 biovar El Tor]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T145897 NZ_CP062708:c458523-458038 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT145897 WP_001882332.1 NZ_CP047304:425458-425883 [Vibrio cholerae O1 biovar El Tor]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT145897 NZ_CP062708:c458792-458514 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References