Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 432818..433346 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ80_RS16775 Protein ID WP_000221352.1
Coordinates 432818..433108 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ80_RS16780 Protein ID WP_000213183.1
Coordinates 433098..433346 (-) Length 83 a.a.

Genomic Context

ASZ80_RS20990ASZ80_RS20995ASZ80_RS16745ASZ80_RS16750ASZ80_RS16755ASZ80_RS20650ASZ80_RS16765ASZ80_RS16770ASZ80_RS16790ASZ80_RS16795ASZ80_RS16800ASZ80_RS16805ASZ80_RS16810ASZ80_RS16815ASZ80_RS16775ASZ80_RS16780ASZ80_RS16820
Location: 428375..428500 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 428516..428554 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 428767..429771 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 429924..430370 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 430490..431419 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 431416..431526 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 431554..432030 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 432167..432682 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 433917..434570 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 434842..435267 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 435475..435870 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 436021..436551 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 436689..437189 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 437345..437743 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 432818..433108 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 433098..433346 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 437843..438307 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS20990428375..428500+126WP_001944767.1DUF645 family protein-
ASZ80_RS20995428516..428554+39WP_106019119.1hypothetical protein-
ASZ80_RS16745428767..429771+1005WP_000964925.1LD-carboxypeptidase-
ASZ80_RS16750429924..430370+447WP_000128977.1hypothetical protein-
ASZ80_RS16755430490..431419+930WP_000335802.1hypothetical protein-
ASZ80_RS20650431416..431526+111WP_071917832.1DUF3265 domain-containing protein-
ASZ80_RS16765431554..432030+477WP_001047180.1GNAT family N-acetyltransferase-
ASZ80_RS16770432167..432682+516WP_001201528.1lipocalin family protein-
ASZ80_RS16775432818..433108-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS16780433098..433346-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ80_RS16790433917..434570+654WP_000036957.1site-specific DNA-methyltransferase-
ASZ80_RS16795434842..435267+426WP_000415748.1hypothetical protein-
ASZ80_RS16800435475..435870+396WP_000649527.1DUF3465 domain-containing protein-
ASZ80_RS16805436021..436551+531WP_000415563.1hypothetical protein-
ASZ80_RS16810436689..437189+501WP_000789723.1hypothetical protein-
ASZ80_RS16815437345..437743+399WP_001882293.1hypothetical protein-
ASZ80_RS16820437843..438307-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58226 WP_000221352.1 NZ_CP013302:c433108-432818 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58226 NZ_CP013302:c433108-432818 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58226 WP_000213183.1 NZ_CP013302:c433346-433098 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58226 NZ_CP013302:c433346-433098 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References