58226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 432818..433346 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ80_RS16775 Protein ID WP_000221352.1
Coordinates 432818..433108 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ80_RS16780 Protein ID WP_000213183.1
Coordinates 433098..433346 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS20990 428375..428500 + 126 WP_001944767.1 DUF645 family protein -
ASZ80_RS20995 428516..428554 + 39 WP_106019119.1 hypothetical protein -
ASZ80_RS16745 428767..429771 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ80_RS16750 429924..430370 + 447 WP_000128977.1 hypothetical protein -
ASZ80_RS16755 430490..431419 + 930 WP_000335802.1 hypothetical protein -
ASZ80_RS20650 431416..431526 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ80_RS16765 431554..432030 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
ASZ80_RS16770 432167..432682 + 516 WP_001201528.1 lipocalin family protein -
ASZ80_RS16775 432818..433108 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ80_RS16780 433098..433346 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ80_RS16790 433917..434570 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ80_RS16795 434842..435267 + 426 WP_000415748.1 hypothetical protein -
ASZ80_RS16800 435475..435870 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ80_RS16805 436021..436551 + 531 WP_000415563.1 hypothetical protein -
ASZ80_RS16810 436689..437189 + 501 WP_000789723.1 hypothetical protein -
ASZ80_RS16815 437345..437743 + 399 WP_001882293.1 hypothetical protein -
ASZ80_RS16820 437843..438307 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58226 WP_000221352.1 NZ_CP013302:c433108-432818 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58226 NZ_CP013302:c433108-432818 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58226 WP_000213183.1 NZ_CP013302:c433346-433098 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58226 NZ_CP013302:c433346-433098 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References