Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 47753..48331 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HJ37_RS14225 Protein ID WP_001180243.1
Coordinates 47753..48070 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag HJ37_RS14230 Protein ID WP_000557292.1
Coordinates 48089..48331 (-) Length 81 a.a.

Genomic Context

HJ37_RS14190HJ37_RS19860HJ37_RS14205HJ37_RS14210HJ37_RS14215HJ37_RS14220HJ37_RS14235HJ37_RS19360HJ37_RS14240HJ37_RS14250HJ37_RS14255HJ37_RS19880HJ37_RS19885HJ37_RS14280HJ37_RS14225HJ37_RS14230HJ37_RS14260HJ37_RS14265
Location: 43278..43460 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 43814..43995 (182 bp)
Type: Others
Protein ID: Protein_48
Location: 44190..44867 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 45029..46237 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 46399..47103 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 47261..47599 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 48575..48961 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 49018..49131 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49140..49360 (221 bp)
Type: Others
Protein ID: Protein_57
Location: 49618..50154 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50291..50806 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52115..52240 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52256..52294 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52489..52935 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 47753..48070 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 48089..48331 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 50956..51453 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 51450..51722 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS1419043278..43460+183WP_000923340.1DUF645 family protein-
HJ37_RS1986043814..43995+182Protein_48DUF645 family protein-
HJ37_RS1420544190..44867+678WP_000254617.1HNH endonuclease-
HJ37_RS1421045029..46237+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
HJ37_RS1421546399..47103+705WP_000087610.1HNH endonuclease-
HJ37_RS1422047261..47599+339WP_000713853.1hypothetical protein-
HJ37_RS1422547753..48070-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HJ37_RS1423048089..48331-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
HJ37_RS1423548575..48961+387WP_001015867.1NUDIX hydrolase-
HJ37_RS1936049018..49131+114WP_001900214.1hypothetical protein-
HJ37_RS1424049140..49360+221Protein_57DUF1289 domain-containing protein-
HJ37_RS1425049618..50154+537WP_000469482.1GNAT family N-acetyltransferase-
HJ37_RS1425550291..50806+516WP_001201509.1lipocalin family protein-
HJ37_RS1426050956..51453-498WP_000982260.1GNAT family N-acetyltransferase-
HJ37_RS1426551450..51722-273WP_000246253.1DUF1778 domain-containing protein-
HJ37_RS1988052115..52240+126WP_001900195.1DUF645 family protein-
HJ37_RS1988552256..52294+39WP_106019118.1hypothetical protein-
HJ37_RS1428052489..52935+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T25705 WP_001180243.1 NC_016446:c48070-47753 [Vibrio cholerae O1 str. 2010EL-1786]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T25705 NC_016446:c48070-47753 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT25705 WP_000557292.1 NC_016446:c48331-48089 [Vibrio cholerae O1 str. 2010EL-1786]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT25705 NC_016446:c48331-48089 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References