25705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 47753..48331 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HJ37_RS14225 Protein ID WP_001180243.1
Coordinates 47753..48070 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag HJ37_RS14230 Protein ID WP_000557292.1
Coordinates 48089..48331 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14190 43278..43460 + 183 WP_000923340.1 DUF645 family protein -
HJ37_RS19860 43814..43995 + 182 Protein_48 DUF645 family protein -
HJ37_RS14205 44190..44867 + 678 WP_000254617.1 HNH endonuclease -
HJ37_RS14210 45029..46237 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
HJ37_RS14215 46399..47103 + 705 WP_000087610.1 HNH endonuclease -
HJ37_RS14220 47261..47599 + 339 WP_000713853.1 hypothetical protein -
HJ37_RS14225 47753..48070 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14230 48089..48331 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HJ37_RS14235 48575..48961 + 387 WP_001015867.1 NUDIX hydrolase -
HJ37_RS19360 49018..49131 + 114 WP_001900214.1 hypothetical protein -
HJ37_RS14240 49140..49360 + 221 Protein_57 DUF1289 domain-containing protein -
HJ37_RS14250 49618..50154 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
HJ37_RS14255 50291..50806 + 516 WP_001201509.1 lipocalin family protein -
HJ37_RS14260 50956..51453 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HJ37_RS14265 51450..51722 - 273 WP_000246253.1 DUF1778 domain-containing protein -
HJ37_RS19880 52115..52240 + 126 WP_001900195.1 DUF645 family protein -
HJ37_RS19885 52256..52294 + 39 WP_106019118.1 hypothetical protein -
HJ37_RS14280 52489..52935 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T25705 WP_001180243.1 NC_016446:c48070-47753 [Vibrio cholerae O1 str. 2010EL-1786]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T25705 NC_016446:c48070-47753 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT25705 WP_000557292.1 NC_016446:c48331-48089 [Vibrio cholerae O1 str. 2010EL-1786]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT25705 NC_016446:c48331-48089 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References