Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356206..356784 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ80_RS16000 Protein ID WP_001180243.1
Coordinates 356206..356523 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ80_RS16005 Protein ID WP_000557292.1
Coordinates 356542..356784 (-) Length 81 a.a.

Genomic Context

ASZ80_RS15970ASZ80_RS15975ASZ80_RS15980ASZ80_RS15985ASZ80_RS15990ASZ80_RS15995ASZ80_RS16010ASZ80_RS16015ASZ80_RS16020ASZ80_RS16030ASZ80_RS16035ASZ80_RS20495ASZ80_RS20500ASZ80_RS16055ASZ80_RS16000ASZ80_RS16005ASZ80_RS16040ASZ80_RS16045
Location: 351730..351912 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 352266..352448 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 352643..353320 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 353482..354690 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 354852..355556 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 355714..356052 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 357028..357414 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357471..357584 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357533..357814 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358072..358608 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358745..359260 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360569..360694 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360710..360748 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360944..361390 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 356206..356523 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 356542..356784 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 359410..359907 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 359904..360176 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS15970351730..351912+183WP_000923340.1DUF645 family protein-
ASZ80_RS15975352266..352448+183WP_000923153.1DUF645 family protein-
ASZ80_RS15980352643..353320+678WP_000254617.1HNH endonuclease-
ASZ80_RS15985353482..354690+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ASZ80_RS15990354852..355556+705WP_000087610.1HNH endonuclease-
ASZ80_RS15995355714..356052+339WP_000713853.1hypothetical protein-
ASZ80_RS16000356206..356523-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS16005356542..356784-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ80_RS16010357028..357414+387WP_001015867.1NUDIX hydrolase-
ASZ80_RS16015357471..357584+114WP_001900214.1hypothetical protein-
ASZ80_RS16020357533..357814+282WP_001894429.1DUF1289 domain-containing protein-
ASZ80_RS16030358072..358608+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ80_RS16035358745..359260+516WP_001201509.1lipocalin family protein-
ASZ80_RS16040359410..359907-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ80_RS16045359904..360176-273WP_000246253.1DUF1778 domain-containing protein-
ASZ80_RS20495360569..360694+126WP_001900195.1DUF645 family protein-
ASZ80_RS20500360710..360748+39WP_106019118.1hypothetical protein-
ASZ80_RS16055360944..361390+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58218 WP_001180243.1 NZ_CP013302:c356523-356206 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58218 NZ_CP013302:c356523-356206 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58218 WP_000557292.1 NZ_CP013302:c356784-356542 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58218 NZ_CP013302:c356784-356542 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References