25711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 90418..90996 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HJ37_RS14575 Protein ID WP_001180243.1
Coordinates 90418..90735 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag HJ37_RS14580 Protein ID WP_000557292.1
Coordinates 90754..90996 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14540 85609..86004 + 396 WP_000046952.1 hypothetical protein -
HJ37_RS19480 86307..86488 + 182 Protein_125 DUF645 family protein -
HJ37_RS14545 86665..87060 + 396 WP_000046953.1 hypothetical protein -
HJ37_RS14550 87204..87740 + 537 WP_000644491.1 nucleotidyltransferase family protein -
HJ37_RS14560 88037..88216 + 180 WP_001883039.1 DUF645 family protein -
HJ37_RS14565 88412..88837 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
HJ37_RS14570 88986..89333 + 348 WP_000933409.1 hypothetical protein -
HJ37_RS20120 89480..89773 + 294 WP_125460920.1 hypothetical protein -
HJ37_RS20210 90129..90224 + 96 WP_001907607.1 DUF645 family protein -
HJ37_RS14575 90418..90735 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14580 90754..90996 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HJ37_RS14585 91238..91747 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
HJ37_RS14590 91804..92457 + 654 WP_000226874.1 hypothetical protein -
HJ37_RS14595 92767..92985 + 219 WP_001917086.1 DUF3709 domain-containing protein -
HJ37_RS19510 93388..93621 + 234 WP_032482776.1 DUF3709 domain-containing protein -
HJ37_RS14600 94046..94226 + 181 Protein_139 DUF645 family protein -
HJ37_RS14605 94493..94780 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HJ37_RS14610 94791..95108 + 318 WP_001232701.1 HigA family addiction module antidote protein -
HJ37_RS20215 95105..95215 + 111 WP_134814058.1 DUF3265 domain-containing protein -
HJ37_RS19525 95392..95517 + 126 WP_001944767.1 DUF645 family protein -
HJ37_RS19980 95533..95571 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T25711 WP_001180243.1 NC_016446:c90735-90418 [Vibrio cholerae O1 str. 2010EL-1786]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T25711 NC_016446:c90735-90418 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT25711 WP_000557292.1 NC_016446:c90996-90754 [Vibrio cholerae O1 str. 2010EL-1786]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT25711 NC_016446:c90996-90754 [Vibrio cholerae O1 str. 2010EL-1786]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References