Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 378243..378790 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID C3LV30
Locus tag ASZ85_RS16025 Protein ID WP_000229318.1
Coordinates 378488..378790 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ85_RS16020 Protein ID WP_000861987.1
Coordinates 378243..378500 (+) Length 86 a.a.

Genomic Context

ASZ85_RS15965ASZ85_RS15970ASZ85_RS15980ASZ85_RS15985ASZ85_RS20980ASZ85_RS20985ASZ85_RS16005ASZ85_RS16020ASZ85_RS16025ASZ85_RS16030ASZ85_RS16035ASZ85_RS21000ASZ85_RS16050ASZ85_RS16060ASZ85_RS16065ASZ85_RS16070ASZ85_RS21445ASZ85_RS15990ASZ85_RS15995ASZ85_RS16010ASZ85_RS16015
Location: 373386..373499 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 373448..373729 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 373987..374523 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 374660..375175 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 376484..376609 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 376625..376663 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 376859..377305 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 378243..378500 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 378488..378790 (303 bp)
Type: Toxin
Protein ID: WP_000229318.1
Location: 379079..379303 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 379747..379866 (120 bp)
Type: Others
Protein ID: WP_071919600.1
Location: 379870..379923 (54 bp)
Type: Others
Protein ID: Protein_360
Location: 380525..381529 (1005 bp)
Type: Others
Protein ID: WP_000964931.1
Location: 382304..382484 (181 bp)
Type: Others
Protein ID: Protein_362
Location: 382751..383038 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 383049..383366 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 383363..383473 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 375325..375822 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 375819..376091 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 377453..377722 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 377715..377993 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS15965373386..373499+114WP_001900214.1hypothetical protein-
ASZ85_RS15970373448..373729+282WP_001894429.1DUF1289 domain-containing protein-
ASZ85_RS15980373987..374523+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ85_RS15985374660..375175+516WP_001201509.1lipocalin family protein-
ASZ85_RS15990375325..375822-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ85_RS15995375819..376091-273WP_000246253.1DUF1778 domain-containing protein-
ASZ85_RS20980376484..376609+126WP_001900195.1DUF645 family protein-
ASZ85_RS20985376625..376663+39WP_106019118.1hypothetical protein-
ASZ85_RS16005376859..377305+447WP_000006157.1hypothetical protein-
ASZ85_RS16010377453..377722-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
ASZ85_RS16015377715..377993-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ85_RS16020378243..378500+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ85_RS16025378488..378790+303WP_000229318.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS16030379079..379303+225WP_001894423.1DUF3709 domain-containing protein-
ASZ85_RS16035379747..379866+120WP_071919600.1DUF645 family protein-
ASZ85_RS21000379870..379923+54Protein_360DUF645 family protein-
ASZ85_RS16050380525..381529+1005WP_000964931.1LD-carboxypeptidase-
ASZ85_RS16060382304..382484+181Protein_362DUF645 family protein-
ASZ85_RS16065382751..383038+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ85_RS16070383049..383366+318WP_001232701.1HigA family addiction module antidote protein-
ASZ85_RS21445383363..383473+111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 5.1972

>T58396 WP_000229318.1 NZ_CP013318:378488-378790 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58396 NZ_CP013318:378488-378790 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58396 WP_000861987.1 NZ_CP013318:378243-378500 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58396 NZ_CP013318:378243-378500 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC3LV30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References