88992

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 347842..348380 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag VCA1552_RS16035 Protein ID WP_000802136.1
Coordinates 347842..348141 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag VCA1552_RS16040 Protein ID WP_001107719.1
Coordinates 348138..348380 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS15985 343777..343959 + 183 WP_000923182.1 DUF645 family protein -
VCA1552_RS15990 344159..344632 + 474 WP_001161076.1 GrpB family protein -
VCA1552_RS15995 344629..344739 + 111 WP_071908312.1 DUF3265 domain-containing protein -
VCA1552_RS16000 344781..345407 + 627 WP_000365424.1 LysE family translocator -
VCA1552_RS16005 345530..346228 + 699 WP_001890502.1 hypothetical protein -
VCA1552_RS16010 346232..346348 + 117 WP_071908339.1 DUF3265 domain-containing protein -
VCA1552_RS16025 346926..347105 + 180 WP_001883058.1 DUF645 family protein -
VCA1552_RS16030 347319..347714 + 396 WP_000870857.1 DUF3465 domain-containing protein -
VCA1552_RS16035 347842..348141 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS16040 348138..348380 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
VCA1552_RS16050 348609..349187 + 579 WP_000110120.1 hypothetical protein -
VCA1552_RS16055 349191..349301 + 111 WP_071908313.1 DUF3265 domain-containing protein -
VCA1552_RS16065 349725..350408 + 684 WP_000877436.1 hypothetical protein -
VCA1552_RS16075 350622..350888 + 267 WP_000937852.1 hypothetical protein -
VCA1552_RS16085 351043..351642 + 600 WP_000429495.1 hypothetical protein -
VCA1552_RS16090 351923..352858 + 936 WP_000051985.1 restriction endonuclease -
VCA1552_RS16095 352824..352964 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T88992 WP_000802136.1 NZ_CP024868:c348141-347842 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T88992 NZ_CP024868:c348141-347842 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT88992 WP_001107719.1 NZ_CP024868:c348380-348138 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT88992 NZ_CP024868:c348380-348138 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References