92513

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 417565..418093 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag C1H56_RS16750 Protein ID WP_000221354.1
Coordinates 417806..418093 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag C1H56_RS16745 Protein ID WP_001250179.1
Coordinates 417565..417816 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS16705 412833..413147 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
C1H56_RS16710 413284..413718 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
C1H56_RS19860 413886..414041 + 156 WP_000751734.1 hypothetical protein -
C1H56_RS16715 414166..415146 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
C1H56_RS16720 415214..415486 + 273 Protein_444 CatB-related O-acetyltransferase -
C1H56_RS16725 415657..416349 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
C1H56_RS16730 416349..416750 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
C1H56_RS16735 416720..416863 + 144 WP_071908341.1 DUF3265 domain-containing protein -
C1H56_RS16740 416938..417351 + 414 WP_000049417.1 VOC family protein -
C1H56_RS16745 417565..417816 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1H56_RS16750 417806..418093 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H56_RS16755 418221..418676 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
C1H56_RS16760 418998..419150 + 153 WP_001884520.1 DUF645 family protein -
C1H56_RS16770 419352..419849 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
C1H56_RS16775 419846..420118 - 273 WP_000246253.1 DUF1778 domain-containing protein -
C1H56_RS16780 420349..421017 + 669 WP_000043871.1 hypothetical protein -
C1H56_RS16785 421169..421456 + 288 WP_000426470.1 hypothetical protein -
C1H56_RS16790 421597..421968 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
C1H56_RS20010 422035..422460 + 426 WP_001882332.1 DUF1778 domain-containing protein -
C1H56_RS16800 422457..422990 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805
flank IS/Tn - - 414166..415146 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T92513 WP_000221354.1 NZ_CP025937:417806-418093 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T92513 NZ_CP025937:417806-418093 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT92513 WP_001250179.1 NZ_CP025937:417565-417816 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT92513 NZ_CP025937:417565-417816 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References