Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 417565..418093 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag C1H56_RS16750 Protein ID WP_000221354.1
Coordinates 417806..418093 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag C1H56_RS16745 Protein ID WP_001250179.1
Coordinates 417565..417816 (+) Length 84 a.a.

Genomic Context

C1H56_RS16705C1H56_RS16710C1H56_RS19860C1H56_RS16720C1H56_RS16725C1H56_RS16730C1H56_RS16735C1H56_RS16740C1H56_RS16745C1H56_RS16750C1H56_RS16755C1H56_RS16760C1H56_RS16780C1H56_RS16785C1H56_RS16790C1H56_RS20010C1H56_RS16800C1H56_RS16715C1H56_RS16770C1H56_RS16775
Location: 412833..413147 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413284..413718 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 413886..414041 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415214..415486 (273 bp)
Type: Others
Protein ID: Protein_444
Location: 415657..416349 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416349..416750 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 416720..416863 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 416938..417351 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 417565..417816 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 417806..418093 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 418221..418676 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418998..419150 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420349..421017 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421169..421456 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 421597..421968 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422035..422460 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 422457..422990 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 414166..415146 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 419352..419849 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419846..420118 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS16705412833..413147+315WP_000071008.1DNA-binding transcriptional regulator-
C1H56_RS16710413284..413718+435WP_000256036.1GNAT family N-acetyltransferase-
C1H56_RS19860413886..414041+156WP_000751734.1hypothetical protein-
C1H56_RS16715414166..415146-981WP_000019370.1IS5-like element ISVch5 family transposase-
C1H56_RS16720415214..415486+273Protein_444CatB-related O-acetyltransferase-
C1H56_RS16725415657..416349+693WP_001047169.1GNAT family N-acetyltransferase-
C1H56_RS16730416349..416750+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
C1H56_RS16735416720..416863+144WP_071908341.1DUF3265 domain-containing protein-
C1H56_RS16740416938..417351+414WP_000049417.1VOC family protein-
C1H56_RS16745417565..417816+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C1H56_RS16750417806..418093+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C1H56_RS16755418221..418676+456WP_001245327.1GNAT family N-acetyltransferase-
C1H56_RS16760418998..419150+153WP_001884520.1DUF645 family protein-
C1H56_RS16770419352..419849-498WP_000982260.1GNAT family N-acetyltransferase-
C1H56_RS16775419846..420118-273WP_000246253.1DUF1778 domain-containing protein-
C1H56_RS16780420349..421017+669WP_000043871.1hypothetical protein-
C1H56_RS16785421169..421456+288WP_000426470.1hypothetical protein-
C1H56_RS16790421597..421968+372WP_001164080.1nucleotide pyrophosphohydrolase-
C1H56_RS20010422035..422460+426WP_001882332.1DUF1778 domain-containing protein-
C1H56_RS16800422457..422990+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805
flankIS/Tn--414166..415146980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T92513 WP_000221354.1 NZ_CP025937:417806-418093 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T92513 NZ_CP025937:417806-418093 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT92513 WP_001250179.1 NZ_CP025937:417565-417816 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT92513 NZ_CP025937:417565-417816 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References