Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 431319..431723 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag A1552VC_RS16900 Protein ID WP_001114075.1
Coordinates 431454..431723 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag A1552VC_RS16895 Protein ID WP_099607150.1
Coordinates 431319..431423 (+) Length 35 a.a.

Genomic Context

A1552VC_RS16860A1552VC_RS16865A1552VC_RS16870A1552VC_RS16875A1552VC_RS16880A1552VC_RS16885A1552VC_RS16890A1552VC_RS16895A1552VC_RS16900A1552VC_RS16905A1552VC_RS16910A1552VC_RS16920A1552VC_RS16935A1552VC_RS16945A1552VC_RS16925A1552VC_RS16930
Location: 426820..427737 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427894..428283 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428419..428628 (210 bp)
Type: Others
Protein ID: Protein_465
Location: 428747..429184 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429248..429466 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429641..430513 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430663..431262 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431319..431423 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 431454..431723 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431717..432238 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 432537..432662 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432913..433308 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434200..434715 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434899..435312 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 433447..433725 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433722..434006 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS16860426820..427737+918WP_000186333.1alpha/beta hydrolase-
A1552VC_RS16865427894..428283+390WP_001081302.1hypothetical protein-
A1552VC_RS16870428419..428628+210Protein_465GNAT family N-acetyltransferase-
A1552VC_RS16875428747..429184+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
A1552VC_RS16880429248..429466+219WP_071908318.1GNAT family N-acetyltransferase-
A1552VC_RS16885429641..430513+873WP_000254716.1DUF3800 domain-containing protein-
A1552VC_RS16890430663..431262+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
A1552VC_RS16895431319..431423+105WP_099607150.1acetyltransferaseAntitoxin
A1552VC_RS16900431454..431723+270WP_001114075.1DUF4160 domain-containing proteinToxin
A1552VC_RS16905431717..432238+522WP_000921691.1DUF2442 domain-containing protein-
A1552VC_RS16910432537..432662+126WP_001905700.1DUF645 family protein-
A1552VC_RS16920432913..433308+396WP_001000867.1hypothetical protein-
A1552VC_RS16925433447..433725-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
A1552VC_RS16930433722..434006-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
A1552VC_RS16935434200..434715+516WP_000343779.1GNAT family N-acetyltransferase-
A1552VC_RS16945434899..435312+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--428747..429184437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T104350 WP_001114075.1 NZ_CP028895:431454-431723 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T104350 NZ_CP028895:431454-431723 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT104350 WP_099607150.1 NZ_CP028895:431319-431423 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT104350 NZ_CP028895:431319-431423 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References