Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 350030..350568 | Replicon | chromosome |
| Accession | NZ_CP047296 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GTF72_RS15430 | Protein ID | WP_000802136.1 |
| Coordinates | 350030..350329 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | GTF72_RS15435 | Protein ID | WP_001107719.1 |
| Coordinates | 350326..350568 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTF72_RS15390 | 345965..346147 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| GTF72_RS15395 | 346347..346820 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| GTF72_RS15400 | 346817..346927 | + | 111 | WP_071908312.1 | DUF3265 domain-containing protein | - |
| GTF72_RS15405 | 346969..347595 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| GTF72_RS15410 | 347718..348416 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| GTF72_RS15415 | 348420..348536 | + | 117 | WP_071908339.1 | DUF3265 domain-containing protein | - |
| GTF72_RS15420 | 349114..349293 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
| GTF72_RS15425 | 349507..349902 | + | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| GTF72_RS15430 | 350030..350329 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GTF72_RS15435 | 350326..350568 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GTF72_RS15440 | 350797..351375 | + | 579 | WP_000110120.1 | hypothetical protein | - |
| GTF72_RS15445 | 351379..351489 | + | 111 | WP_071908313.1 | DUF3265 domain-containing protein | - |
| GTF72_RS15450 | 351913..352596 | + | 684 | WP_000877436.1 | hypothetical protein | - |
| GTF72_RS15455 | 352810..353076 | + | 267 | WP_000937852.1 | hypothetical protein | - |
| GTF72_RS15460 | 353231..353830 | + | 600 | WP_000429495.1 | hypothetical protein | - |
| GTF72_RS15465 | 354111..355046 | + | 936 | WP_000051985.1 | restriction endonuclease | - |
| GTF72_RS15470 | 355012..355152 | + | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 306905..436165 | 129260 | |
| inside | Integron | - | - | 311985..435789 | 123804 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T145808 WP_000802136.1 NZ_CP047296:c350329-350030 [Vibrio cholerae C6706]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T145808 NZ_CP062700:739580-739894 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT145808 WP_001107719.1 NZ_CP047296:c350568-350326 [Vibrio cholerae C6706]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT145808 NZ_CP062700:739891-740307 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|