Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350030..350568 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF72_RS15430 Protein ID WP_000802136.1
Coordinates 350030..350329 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF72_RS15435 Protein ID WP_001107719.1
Coordinates 350326..350568 (-) Length 81 a.a.

Genomic Context

GTF72_RS15390GTF72_RS15395GTF72_RS15400GTF72_RS15405GTF72_RS15410GTF72_RS15415GTF72_RS15420GTF72_RS15425GTF72_RS15440GTF72_RS15445GTF72_RS15450GTF72_RS15455GTF72_RS15460GTF72_RS15465GTF72_RS15470GTF72_RS15430GTF72_RS15435
Location: 345965..346147 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346347..346820 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346817..346927 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 346969..347595 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347718..348416 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348420..348536 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 349114..349293 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 349507..349902 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 350797..351375 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 351379..351489 (111 bp)
Type: Others
Protein ID: WP_071908313.1
Location: 351913..352596 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 352810..353076 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 353231..353830 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 354111..355046 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 355012..355152 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 350030..350329 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 350326..350568 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15390345965..346147+183WP_000923182.1DUF645 family protein-
GTF72_RS15395346347..346820+474WP_001161076.1GrpB family protein-
GTF72_RS15400346817..346927+111WP_071908312.1DUF3265 domain-containing protein-
GTF72_RS15405346969..347595+627WP_000365424.1LysE family translocator-
GTF72_RS15410347718..348416+699WP_001890502.1hypothetical protein-
GTF72_RS15415348420..348536+117WP_071908339.1DUF3265 domain-containing protein-
GTF72_RS15420349114..349293+180WP_001883058.1DUF645 family protein-
GTF72_RS15425349507..349902+396WP_000870857.1DUF3465 domain-containing protein-
GTF72_RS15430350030..350329-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS15435350326..350568-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
GTF72_RS15440350797..351375+579WP_000110120.1hypothetical protein-
GTF72_RS15445351379..351489+111WP_071908313.1DUF3265 domain-containing protein-
GTF72_RS15450351913..352596+684WP_000877436.1hypothetical protein-
GTF72_RS15455352810..353076+267WP_000937852.1hypothetical protein-
GTF72_RS15460353231..353830+600WP_000429495.1hypothetical protein-
GTF72_RS15465354111..355046+936WP_000051985.1restriction endonuclease-
GTF72_RS15470355012..355152+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145808 WP_000802136.1 NZ_CP047296:c350329-350030 [Vibrio cholerae C6706]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145808 NZ_CP062700:739580-739894 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145808 WP_001107719.1 NZ_CP047296:c350568-350326 [Vibrio cholerae C6706]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145808 NZ_CP062700:739891-740307 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References