58224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 398873..399451 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ80_RS16435 Protein ID WP_001180243.1
Coordinates 398873..399190 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ80_RS16440 Protein ID WP_000557292.1
Coordinates 399209..399451 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS16385 394064..394459 + 396 WP_000046952.1 hypothetical protein -
ASZ80_RS16390 394762..394943 + 182 Protein_405 DUF645 family protein -
ASZ80_RS16395 395120..395515 + 396 WP_000046953.1 hypothetical protein -
ASZ80_RS16400 395659..396195 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ80_RS16405 396492..396671 + 180 WP_001883039.1 DUF645 family protein -
ASZ80_RS16410 396867..397292 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ80_RS16415 397441..397788 + 348 WP_000933409.1 hypothetical protein -
ASZ80_RS20580 397935..398228 + 294 WP_125460920.1 hypothetical protein -
ASZ80_RS20965 398584..398679 + 96 WP_001907607.1 DUF645 family protein -
ASZ80_RS16435 398873..399190 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ80_RS16440 399209..399451 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ80_RS16445 399693..400202 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ80_RS16450 400259..400912 + 654 WP_000226874.1 hypothetical protein -
ASZ80_RS16455 401222..401440 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ80_RS16465 401843..402076 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ80_RS16470 402501..402681 + 181 Protein_419 DUF645 family protein -
ASZ80_RS16475 402948..403235 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ80_RS16480 403246..403563 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ80_RS20970 403560..403670 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ80_RS20975 403847..403972 + 126 WP_001944767.1 DUF645 family protein -
ASZ80_RS20980 403988..404026 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58224 WP_001180243.1 NZ_CP013302:c399190-398873 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58224 NZ_CP013302:c399190-398873 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58224 WP_000557292.1 NZ_CP013302:c399451-399209 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58224 NZ_CP013302:c399451-399209 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References