Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 398873..399451 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ80_RS16435 Protein ID WP_001180243.1
Coordinates 398873..399190 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ80_RS16440 Protein ID WP_000557292.1
Coordinates 399209..399451 (-) Length 81 a.a.

Genomic Context

ASZ80_RS16385ASZ80_RS16390ASZ80_RS16395ASZ80_RS16400ASZ80_RS16405ASZ80_RS16410ASZ80_RS16415ASZ80_RS20580ASZ80_RS20965ASZ80_RS16445ASZ80_RS16450ASZ80_RS16455ASZ80_RS16465ASZ80_RS16470ASZ80_RS16475ASZ80_RS16480ASZ80_RS20970ASZ80_RS20975ASZ80_RS20980ASZ80_RS16435ASZ80_RS16440
Location: 394064..394459 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 394762..394943 (182 bp)
Type: Others
Protein ID: Protein_405
Location: 395120..395515 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 395659..396195 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 396492..396671 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 396867..397292 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 397441..397788 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 397935..398228 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 398584..398679 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 399693..400202 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 400259..400912 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 401222..401440 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 401843..402076 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 402501..402681 (181 bp)
Type: Others
Protein ID: Protein_419
Location: 402948..403235 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 403246..403563 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 403560..403670 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 403847..403972 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 403988..404026 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 398873..399190 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 399209..399451 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS16385394064..394459+396WP_000046952.1hypothetical protein-
ASZ80_RS16390394762..394943+182Protein_405DUF645 family protein-
ASZ80_RS16395395120..395515+396WP_000046953.1hypothetical protein-
ASZ80_RS16400395659..396195+537WP_000644491.1nucleotidyltransferase family protein-
ASZ80_RS16405396492..396671+180WP_001883039.1DUF645 family protein-
ASZ80_RS16410396867..397292+426WP_000403014.1GNAT family N-acetyltransferase-
ASZ80_RS16415397441..397788+348WP_000933409.1hypothetical protein-
ASZ80_RS20580397935..398228+294WP_125460920.1hypothetical protein-
ASZ80_RS20965398584..398679+96WP_001907607.1DUF645 family protein-
ASZ80_RS16435398873..399190-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS16440399209..399451-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ80_RS16445399693..400202+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ80_RS16450400259..400912+654WP_000226874.1hypothetical protein-
ASZ80_RS16455401222..401440+219WP_001917086.1DUF3709 domain-containing protein-
ASZ80_RS16465401843..402076+234WP_032482776.1DUF3709 domain-containing protein-
ASZ80_RS16470402501..402681+181Protein_419DUF645 family protein-
ASZ80_RS16475402948..403235+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ80_RS16480403246..403563+318WP_001232701.1HigA family addiction module antidote protein-
ASZ80_RS20970403560..403670+111WP_134814058.1DUF3265 domain-containing protein-
ASZ80_RS20975403847..403972+126WP_001944767.1DUF645 family protein-
ASZ80_RS20980403988..404026+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58224 WP_001180243.1 NZ_CP013302:c399190-398873 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58224 NZ_CP013302:c399190-398873 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58224 WP_000557292.1 NZ_CP013302:c399451-399209 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58224 NZ_CP013302:c399451-399209 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References