Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 51795..52333 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K6J77_RS14265 Protein ID WP_000802136.1
Coordinates 51795..52094 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K6J77_RS14270 Protein ID WP_001107719.1
Coordinates 52091..52333 (-) Length 81 a.a.

Genomic Context

K6J77_RS19005K6J77_RS14225K6J77_RS14230K6J77_RS14235K6J77_RS14240K6J77_RS14245K6J77_RS14250K6J77_RS14255K6J77_RS14260K6J77_RS14275K6J77_RS14280K6J77_RS14285K6J77_RS14290K6J77_RS14295K6J77_RS14300K6J77_RS14305K6J77_RS14265K6J77_RS14270
Location: 47532..47669 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 47730..47912 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 48112..48585 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 48600..48692 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 48734..49360 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 49483..50181 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 50212..50301 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 50879..51058 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 51272..51667 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 52562..53140 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 53162..53254 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 53678..54361 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 54575..54841 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 54996..55595 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 55876..56811 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 56777..56917 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 51795..52094 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 52091..52333 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1900547532..47669+138WP_001890145.1hypothetical protein-
K6J77_RS1422547730..47912+183WP_000923182.1DUF645 family protein-
K6J77_RS1423048112..48585+474WP_001161076.1GrpB family protein-
K6J77_RS1423548600..48692+93WP_014378730.1DUF3265 domain-containing protein-
K6J77_RS1424048734..49360+627WP_000365424.1LysE family translocator-
K6J77_RS1424549483..50181+699WP_001890502.1hypothetical protein-
K6J77_RS1425050212..50301+90WP_072606010.1DUF3265 domain-containing protein-
K6J77_RS1425550879..51058+180WP_001883058.1DUF645 family protein-
K6J77_RS1426051272..51667+396WP_000870857.1DUF3465 domain-containing protein-
K6J77_RS1426551795..52094-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1427052091..52333-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
K6J77_RS1427552562..53140+579WP_000110120.1hypothetical protein-
K6J77_RS1428053162..53254+93WP_014164112.1DUF3265 domain-containing protein-
K6J77_RS1428553678..54361+684WP_000877436.1hypothetical protein-
K6J77_RS1429054575..54841+267WP_000937852.1hypothetical protein-
K6J77_RS1429554996..55595+600WP_000429495.1DUF6338 family protein-
K6J77_RS1430055876..56811+936WP_000051985.1restriction endonuclease-
K6J77_RS1430556777..56917+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T38621 WP_000802136.1 NZ_AP024548:c52094-51795 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T38621 NZ_AP024548:c52094-51795 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT38621 WP_001107719.1 NZ_AP024548:c52333-52091 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT38621 NZ_AP024548:c52333-52091 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References