38621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 51795..52333 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K6J77_RS14265 Protein ID WP_000802136.1
Coordinates 51795..52094 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K6J77_RS14270 Protein ID WP_001107719.1
Coordinates 52091..52333 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS19005 47532..47669 + 138 WP_001890145.1 hypothetical protein -
K6J77_RS14225 47730..47912 + 183 WP_000923182.1 DUF645 family protein -
K6J77_RS14230 48112..48585 + 474 WP_001161076.1 GrpB family protein -
K6J77_RS14235 48600..48692 + 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J77_RS14240 48734..49360 + 627 WP_000365424.1 LysE family translocator -
K6J77_RS14245 49483..50181 + 699 WP_001890502.1 hypothetical protein -
K6J77_RS14250 50212..50301 + 90 WP_072606010.1 DUF3265 domain-containing protein -
K6J77_RS14255 50879..51058 + 180 WP_001883058.1 DUF645 family protein -
K6J77_RS14260 51272..51667 + 396 WP_000870857.1 DUF3465 domain-containing protein -
K6J77_RS14265 51795..52094 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14270 52091..52333 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K6J77_RS14275 52562..53140 + 579 WP_000110120.1 hypothetical protein -
K6J77_RS14280 53162..53254 + 93 WP_014164112.1 DUF3265 domain-containing protein -
K6J77_RS14285 53678..54361 + 684 WP_000877436.1 hypothetical protein -
K6J77_RS14290 54575..54841 + 267 WP_000937852.1 hypothetical protein -
K6J77_RS14295 54996..55595 + 600 WP_000429495.1 DUF6338 family protein -
K6J77_RS14300 55876..56811 + 936 WP_000051985.1 restriction endonuclease -
K6J77_RS14305 56777..56917 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T38621 WP_000802136.1 NZ_AP024548:c52094-51795 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T38621 NZ_AP024548:c52094-51795 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT38621 WP_001107719.1 NZ_AP024548:c52333-52091 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT38621 NZ_AP024548:c52333-52091 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References