Detailed information of TA system TA145408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 406438..407222
• Replicon: chromosome
• Accession: NZ_CP047060
• Organism: Vibrio cholerae isolate CTMA_1441

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: GQX72_RS16010
• Protein ID: WP_001114075.1
• Coordinates: 406438..406707 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: GQX72_RS16015
• Protein ID: WP_000921691.1
• Coordinates: 406701..407222 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX72_RS15970	401804..402721	+	918	WP_000186333.1	alpha/beta hydrolase	-
GQX72_RS15975	402878..403267	+	390	WP_001081302.1	hypothetical protein	-
GQX72_RS15980	403403..403612	+	210	Protein_424	GNAT family N-acetyltransferase	-
GQX72_RS15985	403731..404168	+	438	WP_000503164.1	IS200/IS605-like element IS1004 family transposase	-
GQX72_RS15990	404232..404450	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
GQX72_RS15995	404625..405497	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
GQX72_RS16000	405647..406246	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
GQX72_RS16005	406303..406407	+	105	WP_099607150.1	acetyltransferase	-
GQX72_RS16010	406438..406707	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
GQX72_RS16015	406701..407222	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
GQX72_RS16020	407521..407646	+	126	WP_001905700.1	DUF645 family protein	-
GQX72_RS16030	407897..408292	+	396	WP_001000867.1	hypothetical protein	-
GQX72_RS16035	408431..408709	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GQX72_RS16040	408706..408990	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GQX72_RS16045	409184..409699	+	516	WP_000343779.1	GNAT family N-acetyltransferase	-
GQX72_RS16050	409883..410296	+	414	WP_000049420.1	VOC family protein	-
GQX72_RS16065	410851..412028	+	1178	WP_086010879.1	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	305960..411159	105199
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	311040..410783	99743
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0.002	flank	IS/Tn	-	-	403731..404168	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T145408 WP_001114075.1 NZ_CP047060:406438-406707 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T145408 NZ_CP062376:2731306-2731557 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT145408 WP_000921691.1 NZ_CP047060:406701-407222 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT145408 NZ_CP062376:2731547-2731720 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84