Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 436126..436741 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag IT766_RS15835 Protein ID WP_001162670.1
Coordinates 436126..436413 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IT766_RS15840 Protein ID WP_001232701.1
Coordinates 436424..436741 (+) Length 106 a.a.

Genomic Context

IT766_RS15795IT766_RS15810IT766_RS15815IT766_RS15820IT766_RS15825IT766_RS15830IT766_RS15835IT766_RS15840IT766_RS15845IT766_RS15850IT766_RS15855IT766_RS15860IT766_RS15865IT766_RS15870IT766_RS15875IT766_RS15880IT766_RS15800IT766_RS15805
Location: 431762..431857 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 432871..433380 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 433437..434090 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 434400..434618 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 435021..435254 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 435679..435859 (181 bp)
Type: Others
Protein ID: Protein_416
Location: 436126..436413 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 436424..436741 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 436738..436848 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 437025..437150 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 437166..437204 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 437428..438168 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 438373..439203 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 439260..439742 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 440189..441064 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 441194..441649 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 432051..432368 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 432387..432629 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS15795431762..431857+96WP_001907607.1DUF645 family protein-
IT766_RS15800432051..432368-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
IT766_RS15805432387..432629-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IT766_RS15810432871..433380+510WP_000405987.1GNAT family N-acetyltransferase-
IT766_RS15815433437..434090+654WP_000226874.1hypothetical protein-
IT766_RS15820434400..434618+219WP_001917086.1DUF3709 domain-containing protein-
IT766_RS15825435021..435254+234WP_032482776.1DUF3709 domain-containing protein-
IT766_RS15830435679..435859+181Protein_416DUF645 family protein-
IT766_RS15835436126..436413+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT766_RS15840436424..436741+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
IT766_RS15845436738..436848+111WP_134814058.1DUF3265 domain-containing protein-
IT766_RS15850437025..437150+126WP_001944767.1DUF645 family protein-
IT766_RS15855437166..437204+39WP_106019119.1hypothetical protein-
IT766_RS15860437428..438168+741WP_000469836.1PhzF family phenazine biosynthesis protein-
IT766_RS15865438373..439203+831WP_000056616.1abortive infection family protein-
IT766_RS15870439260..439742+483WP_001895003.1hypothetical protein-
IT766_RS15875440189..441064+876WP_000259044.1hypothetical protein-
IT766_RS15880441194..441649+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T180872 WP_001162670.1 NZ_CP064351:436126-436413 [Vibrio cholerae C6706]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T180872 NZ_CP085767:2065142-2065396 [Enterobacter hormaechei]
GTGAAGATCACATGGTCTGAAGAGGCATGGGAAGACTACCTCTATTGGCAGGAGACCGATAAGCGCATGGTGAGGAAAAT
CAATGAGCTTATCAAAATCTCCTGTCGCACTCCGTTTGAGGGGATCGGCAAGCCAGAGCCATTAAAACATAACCTGGCTG
GCTTCTGGTCTCGCCGAATCACCTCTGAGCATCGCATGGTCTATGCCATCACAGAAGAAGCGATCCTCATAGCTGCGTGC
CGATATCACTACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT180872 WP_001232701.1 NZ_CP064351:436424-436741 [Vibrio cholerae C6706]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT180872 NZ_CP085767:2064894-2065145 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACCATGGTTCAGACGACGGAAGACCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTAGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References