Detailed information of TA system TA180872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 436126..436741
• Replicon: chromosome
• Accession: NZ_CP064351
• Organism: Vibrio cholerae C6706

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q9KMG5
• Locus tag: IT766_RS15835
• Protein ID: WP_001162670.1
• Coordinates: 436126..436413 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IT766_RS15840
• Protein ID: WP_001232701.1
• Coordinates: 436424..436741 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT766_RS15795	431762..431857	+	96	WP_001907607.1	DUF645 family protein	-
IT766_RS15800	432051..432368	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IT766_RS15805	432387..432629	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IT766_RS15810	432871..433380	+	510	WP_000405987.1	GNAT family N-acetyltransferase	-
IT766_RS15815	433437..434090	+	654	WP_000226874.1	hypothetical protein	-
IT766_RS15820	434400..434618	+	219	WP_001917086.1	DUF3709 domain-containing protein	-
IT766_RS15825	435021..435254	+	234	WP_032482776.1	DUF3709 domain-containing protein	-
IT766_RS15830	435679..435859	+	181	Protein_416	DUF645 family protein	-
IT766_RS15835	436126..436413	+	288	WP_001162670.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IT766_RS15840	436424..436741	+	318	WP_001232701.1	HigA family addiction module antidote protein	Antitoxin
IT766_RS15845	436738..436848	+	111	WP_134814058.1	DUF3265 domain-containing protein	-
IT766_RS15850	437025..437150	+	126	WP_001944767.1	DUF645 family protein	-
IT766_RS15855	437166..437204	+	39	WP_106019119.1	hypothetical protein	-
IT766_RS15860	437428..438168	+	741	WP_000469836.1	PhzF family phenazine biosynthesis protein	-
IT766_RS15865	438373..439203	+	831	WP_000056616.1	abortive infection family protein	-
IT766_RS15870	439260..439742	+	483	WP_001895003.1	hypothetical protein	-
IT766_RS15875	440189..441064	+	876	WP_000259044.1	hypothetical protein	-
IT766_RS15880	441194..441649	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	373204..502464	129260
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	378284..502088	123804

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11349.95 Da
• Isoelectric Point: 6.7187

>T180872 WP_001162670.1 NZ_CP064351:436126-436413 [Vibrio cholerae C6706]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Nucleotide

• Length: 288 bp

>T180872 NZ_CP085767:2065142-2065396 [Enterobacter hormaechei]
GTGAAGATCACATGGTCTGAAGAGGCATGGGAAGACTACCTCTATTGGCAGGAGACCGATAAGCGCATGGTGAGGAAAAT
CAATGAGCTTATCAAAATCTCCTGTCGCACTCCGTTTGAGGGGATCGGCAAGCCAGAGCCATTAAAACATAACCTGGCTG
GCTTCTGGTCTCGCCGAATCACCTCTGAGCATCGCATGGTCTATGCCATCACAGAAGAAGCGATCCTCATAGCTGCGTGC
CGATATCACTACTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11705.63 Da
• Isoelectric Point: 10.4711

>AT180872 WP_001232701.1 NZ_CP064351:436424-436741 [Vibrio cholerae C6706]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Nucleotide

• Length: 318 bp

>AT180872 NZ_CP085767:2064894-2065145 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACCATGGTTCAGACGACGGAAGACCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTAGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0F2HI36