Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 484793..485886 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag IT766_RS16255 Protein ID WP_000351248.1
Coordinates 485485..485886 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag IT766_RS16250 Protein ID WP_001047169.1
Coordinates 484793..485485 (+) Length 231 a.a.

Genomic Context

IT766_RS16195IT766_RS16200IT766_RS16205IT766_RS16210IT766_RS16215IT766_RS16220IT766_RS16225IT766_RS16230IT766_RS16235IT766_RS16245IT766_RS16250IT766_RS16255IT766_RS16260IT766_RS16265IT766_RS16270IT766_RS16275IT766_RS16280IT766_RS16285IT766_RS16300IT766_RS16305IT766_RS16240IT766_RS16290IT766_RS16295
Location: 480076..480453 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 480510..480624 (115 bp)
Type: Others
Protein ID: Protein_490
Location: 480573..480854 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 481020..481133 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 481082..481309 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 481650..481982 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 481969..482283 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 482420..482854 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 483022..483177 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 484350..484622 (273 bp)
Type: Others
Protein ID: Protein_499
Location: 484793..485485 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 485485..485886 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 485856..485999 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 486074..486487 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 486701..486952 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 486942..487229 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 487357..487812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 488134..488286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 489485..490153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 490305..490592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 483302..484282 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 488488..488985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 488982..489254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS16195480076..480453+378WP_000411109.1hypothetical protein-
IT766_RS16200480510..480624+115Protein_490acetyltransferase-
IT766_RS16205480573..480854+282WP_001894453.1DUF1289 domain-containing protein-
IT766_RS16210481020..481133+114WP_001889158.1hypothetical protein-
IT766_RS16215481082..481309+228WP_001894457.1DUF1289 domain-containing protein-
IT766_RS16220481650..481982+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
IT766_RS16225481969..482283+315WP_000071008.1DNA-binding transcriptional regulator-
IT766_RS16230482420..482854+435WP_000256036.1GNAT family N-acetyltransferase-
IT766_RS16235483022..483177+156WP_000751734.1hypothetical protein-
IT766_RS16240483302..484282-981WP_000019370.1IS5-like element ISVch5 family transposase-
IT766_RS16245484350..484622+273Protein_499CatB-related O-acetyltransferase-
IT766_RS16250484793..485485+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
IT766_RS16255485485..485886+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
IT766_RS16260485856..485999+144WP_071908341.1DUF3265 domain-containing protein-
IT766_RS16265486074..486487+414WP_000049417.1VOC family protein-
IT766_RS16270486701..486952+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IT766_RS16275486942..487229+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
IT766_RS16280487357..487812+456WP_001245327.1GNAT family N-acetyltransferase-
IT766_RS16285488134..488286+153WP_001884520.1DUF645 family protein-
IT766_RS16290488488..488985-498WP_000982260.1GNAT family N-acetyltransferase-
IT766_RS16295488982..489254-273WP_000246253.1DUF1778 domain-containing protein-
IT766_RS16300489485..490153+669WP_000043871.1hypothetical protein-
IT766_RS16305490305..490592+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804
flankIS/Tn--483302..484282980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T180875 WP_000351248.1 NZ_CP064351:485485-485886 [Vibrio cholerae C6706]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T180875 NZ_CP085767:c2310744-2310442 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT180875 WP_001047169.1 NZ_CP064351:484793-485485 [Vibrio cholerae C6706]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT180875 NZ_CP085767:c2310435-2310148 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAAACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References