25714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 115490..116123 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag HJ37_RS14755 Protein ID WP_000843587.1
Coordinates 115490..115822 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HJ37_RS14760 Protein ID WP_000071008.1
Coordinates 115809..116123 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS20220 110930..111133 + 204 WP_001911745.1 hypothetical protein -
HJ37_RS20010 111414..111588 + 175 Protein_167 DUF3709 domain-containing protein -
HJ37_RS14730 111948..112217 + 270 WP_001198131.1 hypothetical protein -
HJ37_RS20275 112535..112706 + 172 Protein_169 DUF645 family protein -
HJ37_RS14735 112915..113301 + 387 WP_000703163.1 VOC family protein -
HJ37_RS14740 113503..113745 + 243 WP_000107461.1 hypothetical protein -
HJ37_RS14745 113916..114293 + 378 WP_000411109.1 hypothetical protein -
HJ37_RS20235 114350..114464 + 115 Protein_173 acetyltransferase -
HJ37_RS19565 114413..114694 + 282 WP_001894453.1 DUF1289 domain-containing protein -
HJ37_RS19580 114860..114973 + 114 WP_001889158.1 hypothetical protein -
HJ37_RS19585 114922..115149 + 228 WP_001894457.1 DUF1289 domain-containing protein -
HJ37_RS14755 115490..115822 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14760 115809..116123 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
HJ37_RS14765 116260..116694 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
HJ37_RS20240 116862..117017 + 156 WP_000751734.1 hypothetical protein -
HJ37_RS14775 117142..118122 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
HJ37_RS14780 118190..118462 + 273 Protein_182 CatB-related O-acetyltransferase -
HJ37_RS14785 118633..119325 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
HJ37_RS14790 119325..119726 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
HJ37_RS20025 119696..119839 + 144 WP_071908341.1 DUF3265 domain-containing protein -
HJ37_RS14795 119914..120327 + 414 WP_000049417.1 VOC family protein -
HJ37_RS14800 120541..120792 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HJ37_RS14805 120782..121069 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733
flank IS/Tn - - 117142..118122 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-100)

Antitoxin

(43-92)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T25714 WP_000843587.1 NC_016446:115490-115822 [Vibrio cholerae O1 str. 2010EL-1786]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T25714 NC_016446:115490-115822 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT25714 WP_000071008.1 NC_016446:115809-116123 [Vibrio cholerae O1 str. 2010EL-1786]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT25714 NC_016446:115809-116123 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA


Antitoxin

Source ID Structure

References