Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
Location | 115490..116123 | Replicon | chromosome |
Accession | NC_016446 | ||
Organism | Vibrio cholerae O1 str. 2010EL-1786 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMA6 |
Locus tag | HJ37_RS14755 | Protein ID | WP_000843587.1 |
Coordinates | 115490..115822 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HJ37_RS14760 | Protein ID | WP_000071008.1 |
Coordinates | 115809..116123 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HJ37_RS20220 | 110930..111133 | + | 204 | WP_001911745.1 | hypothetical protein | - |
HJ37_RS20010 | 111414..111588 | + | 175 | Protein_167 | DUF3709 domain-containing protein | - |
HJ37_RS14730 | 111948..112217 | + | 270 | WP_001198131.1 | hypothetical protein | - |
HJ37_RS20275 | 112535..112706 | + | 172 | Protein_169 | DUF645 family protein | - |
HJ37_RS14735 | 112915..113301 | + | 387 | WP_000703163.1 | VOC family protein | - |
HJ37_RS14740 | 113503..113745 | + | 243 | WP_000107461.1 | hypothetical protein | - |
HJ37_RS14745 | 113916..114293 | + | 378 | WP_000411109.1 | hypothetical protein | - |
HJ37_RS20235 | 114350..114464 | + | 115 | Protein_173 | acetyltransferase | - |
HJ37_RS19565 | 114413..114694 | + | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
HJ37_RS19580 | 114860..114973 | + | 114 | WP_001889158.1 | hypothetical protein | - |
HJ37_RS19585 | 114922..115149 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
HJ37_RS14755 | 115490..115822 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HJ37_RS14760 | 115809..116123 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
HJ37_RS14765 | 116260..116694 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
HJ37_RS20240 | 116862..117017 | + | 156 | WP_000751734.1 | hypothetical protein | - |
HJ37_RS14775 | 117142..118122 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
HJ37_RS14780 | 118190..118462 | + | 273 | Protein_182 | CatB-related O-acetyltransferase | - |
HJ37_RS14785 | 118633..119325 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
HJ37_RS14790 | 119325..119726 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
HJ37_RS20025 | 119696..119839 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
HJ37_RS14795 | 119914..120327 | + | 414 | WP_000049417.1 | VOC family protein | - |
HJ37_RS14800 | 120541..120792 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
HJ37_RS14805 | 120782..121069 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 31115..136304 | 105189 | |
inside | Integron | catB9 | - | 36195..135928 | 99733 | ||
flank | IS/Tn | - | - | 117142..118122 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T25714 WP_000843587.1 NC_016446:115490-115822 [Vibrio cholerae O1 str. 2010EL-1786]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T25714 NC_016446:115490-115822 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT25714 WP_000071008.1 NC_016446:115809-116123 [Vibrio cholerae O1 str. 2010EL-1786]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT25714 NC_016446:115809-116123 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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