145062

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 337291..337819 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GPY07_RS15860 Protein ID WP_000221354.1
Coordinates 337291..337578 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GPY07_RS15865 Protein ID WP_001250179.1
Coordinates 337568..337819 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS15810 332394..332927 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPY07_RS19430 332924..333349 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPY07_RS15820 333416..333787 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPY07_RS15825 333928..334215 - 288 WP_000426470.1 hypothetical protein -
GPY07_RS15830 334367..335035 - 669 WP_000043871.1 hypothetical protein -
GPY07_RS15835 335266..335538 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY07_RS15840 335535..336032 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY07_RS15850 336234..336386 - 153 WP_001884520.1 DUF645 family protein -
GPY07_RS15855 336708..337163 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
GPY07_RS15860 337291..337578 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS15865 337568..337819 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY07_RS15870 338033..338446 - 414 WP_000049417.1 VOC family protein -
GPY07_RS15875 338521..338664 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPY07_RS15880 338634..339035 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPY07_RS15885 339035..339727 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPY07_RS15890 339864..340170 - 307 Protein_310 CatB-related O-acetyltransferase -
GPY07_RS15895 340238..341218 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GPY07_RS15900 341343..341498 - 156 WP_000751734.1 hypothetical protein -
GPY07_RS15905 341666..342100 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
GPY07_RS15910 342237..342551 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804
flank IS/Tn - - 340238..341218 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145062 WP_000221354.1 NZ_CP046841:c337578-337291 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145062 NZ_CP062252:c3661315-3661034 [Pseudomonas allokribbensis]
ATGACCTATGAGCTGGAGTTCTCGGAGAAAGCCTGGAAAGAATGGAAAAAACTTGATGCGAATCTCAAAGAGCAGTTGAA
GAAGAAACTTCAGGAGCGGCTTGAGAATCCGCATGTTCCAGCCGACCGGCTCAGAGGACTCGGAGGCGCCTACAAGATCA
AGCTTCGGAATGTGGGGTATCGATTGGTCTATCGAGTCAAGGACGAGGTGCTGATCGTGACAGTAATAGCCATTGGTAAA
AGGGAGGGCGGATACGTATACAAAATTGCTACGGAACGTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145062 WP_001250179.1 NZ_CP046841:c337819-337568 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145062 NZ_CP062252:c3661553-3661305 [Pseudomonas allokribbensis]
ATGACACATATAGTCCTTTCCCAAGTCGTAGCGAGCATTTCCGAACTGAAAAAAAATCCCATGGGTACTGTCGCAGCAGG
CGGCGGTGATTCAGTTGCAATTCTCAACCGCAATGAGCCGGCCTTTTATTGCGTCCCGGCAAAAGCCTATGAGGCGCTGA
TGAATCGCCTTGAGGATCTGGAGCTGATTGCTCTGTGCAAGGAACGGGAAAAAGATCCGACCATAAAGGTCTCGATAGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References