Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 354007..354585 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag LVJ30_RS15570 Protein ID WP_001180243.1
Coordinates 354007..354324 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag LVJ30_RS15575 Protein ID WP_000557292.1
Coordinates 354343..354585 (-) Length 81 a.a.

Genomic Context

LVJ30_RS15510LVJ30_RS15515LVJ30_RS15520LVJ30_RS15525LVJ30_RS15530LVJ30_RS15535LVJ30_RS15540LVJ30_RS15545LVJ30_RS15550LVJ30_RS15555LVJ30_RS15560LVJ30_RS15565LVJ30_RS15580LVJ30_RS15585LVJ30_RS15590LVJ30_RS15595LVJ30_RS15600LVJ30_RS15605LVJ30_RS15610LVJ30_RS15615LVJ30_RS15620LVJ30_RS15625LVJ30_RS15630LVJ30_RS15635LVJ30_RS15640LVJ30_RS15645LVJ30_RS15570LVJ30_RS15575
Location: 349393..349593 (201 bp)
Type: Others
Protein ID: WP_233195476.1
Location: 349692..349835 (144 bp)
Type: Others
Protein ID: Protein_336
Location: 349958..350077 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 350254..350649 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 350793..351329 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 351680..351742 (63 bp)
Type: Others
Protein ID: Protein_340
Location: 351732..351842 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 352001..352426 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 352575..352922 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 353069..353362 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 353425..353600 (176 bp)
Type: Others
Protein ID: Protein_345
Location: 353661..353813 (153 bp)
Type: Others
Protein ID: Protein_346
Location: 354827..355336 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 355393..356046 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 356135..356344 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 356356..356574 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 356763..356956 (194 bp)
Type: Others
Protein ID: Protein_353
Location: 356977..357210 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 357635..357815 (181 bp)
Type: Others
Protein ID: Protein_355
Location: 357928..358041 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 358082..358369 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 358380..358697 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 358694..358804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 358843..358953 (111 bp)
Type: Others
Protein ID: Protein_360
Location: 358981..359106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 359069..359185 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 354007..354324 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 354343..354585 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15510 (LVJ30_15515)349393..349593+201WP_233195476.1DUF6404 family protein-
LVJ30_RS15515 (LVJ30_15520)349692..349835+144Protein_336acetyltransferase-
LVJ30_RS15520 (LVJ30_15525)349958..350077+120WP_001900954.1DUF645 family protein-
LVJ30_RS15525 (LVJ30_15530)350254..350649+396WP_000046953.1DUF6404 family protein-
LVJ30_RS15530 (LVJ30_15535)350793..351329+537WP_000644491.1nucleotidyltransferase family protein-
LVJ30_RS15535 (LVJ30_15540)351680..351742+63Protein_340DUF645 family protein-
LVJ30_RS15540 (LVJ30_15545)351732..351842+111WP_223804330.1Tfp pilus assembly protein-
LVJ30_RS15545 (LVJ30_15550)352001..352426+426WP_000403014.1GNAT family N-acetyltransferase-
LVJ30_RS15550 (LVJ30_15555)352575..352922+348WP_000933409.1hypothetical protein-
LVJ30_RS15555 (LVJ30_15560)353069..353362+294WP_125460920.1hypothetical protein-
LVJ30_RS15560 (LVJ30_15565)353425..353600+176Protein_345acetyltransferase-
LVJ30_RS15565 (LVJ30_15570)353661..353813+153Protein_346DUF645 family protein-
LVJ30_RS15570 (LVJ30_15575)354007..354324-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15575 (LVJ30_15580)354343..354585-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LVJ30_RS15580 (LVJ30_15585)354827..355336+510WP_000405987.1GNAT family N-acetyltransferase-
LVJ30_RS15585 (LVJ30_15590)355393..356046+654WP_000226874.1hypothetical protein-
LVJ30_RS15590 (LVJ30_15595)356135..356344+210WP_001900246.1DUF3709 domain-containing protein-
LVJ30_RS15595 (LVJ30_15600)356356..356574+219WP_001917086.1DUF3709 domain-containing protein-
LVJ30_RS15600 (LVJ30_15605)356763..356956+194Protein_353hypothetical protein-
LVJ30_RS15605 (LVJ30_15610)356977..357210+234WP_032482776.1DUF3709 domain-containing protein-
LVJ30_RS15610 (LVJ30_15615)357635..357815+181Protein_355DUF645 family protein-
LVJ30_RS15615 (LVJ30_15620)357928..358041+114WP_001894955.1hypothetical protein-
LVJ30_RS15620 (LVJ30_15625)358082..358369+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
LVJ30_RS15625 (LVJ30_15630)358380..358697+318WP_001232701.1HigA family addiction module antitoxin-
LVJ30_RS15630 (LVJ30_15635)358694..358804+111WP_134814058.1DUF3265 domain-containing protein-
LVJ30_RS15635 (LVJ30_15640)358843..358953+111Protein_360acetyltransferase-
LVJ30_RS15640 (LVJ30_15645)358981..359106+126WP_001944767.1DUF645 family protein-
LVJ30_RS15645 (LVJ30_15650)359069..359185+117WP_001889170.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T230520 WP_001180243.1 NZ_CP090379:c354324-354007 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T230520 NZ_CP124916:c2730383-2730240 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT230520 WP_000557292.1 NZ_CP090379:c354585-354343 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT230520 NZ_CP124916:2730121-2730307 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References