74625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 818922..819500 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag A6J62_RS04080 Protein ID WP_001180243.1
Coordinates 819183..819500 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag A6J62_RS04075 Protein ID WP_000557292.1
Coordinates 818922..819164 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS19570 814347..814385 - 39 WP_106019119.1 hypothetical protein -
A6J62_RS04025 814401..814526 - 126 WP_001944767.1 DUF645 family protein -
A6J62_RS19670 814703..814813 - 111 WP_134814058.1 DUF3265 domain-containing protein -
A6J62_RS04040 814810..815127 - 318 WP_001232701.1 HigA family addiction module antidote protein -
A6J62_RS04045 815138..815425 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6J62_RS04050 815692..815872 - 181 Protein_750 DUF645 family protein -
A6J62_RS04055 816297..816530 - 234 WP_032482776.1 DUF3709 domain-containing protein -
A6J62_RS04060 816933..817151 - 219 WP_001917086.1 DUF3709 domain-containing protein -
A6J62_RS04065 817461..818114 - 654 WP_000226874.1 hypothetical protein -
A6J62_RS04070 818171..818680 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
A6J62_RS04075 818922..819164 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J62_RS04080 819183..819500 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS19675 819694..819789 - 96 WP_001907607.1 DUF645 family protein -
A6J62_RS19575 820145..820438 - 294 WP_125460920.1 hypothetical protein -
A6J62_RS04100 820585..820932 - 348 WP_000933409.1 hypothetical protein -
A6J62_RS04105 821081..821506 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
A6J62_RS04110 821702..821881 - 180 WP_001883039.1 DUF645 family protein -
A6J62_RS04115 822178..822714 - 537 WP_000644491.1 nucleotidyltransferase family protein -
A6J62_RS04120 822858..823253 - 396 WP_000046953.1 hypothetical protein -
A6J62_RS04125 823430..823611 - 182 Protein_764 DUF645 family protein -
A6J62_RS04130 823914..824309 - 396 WP_000046952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T74625 WP_001180243.1 NZ_CP020407:819183-819500 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T74625 NZ_CP020407:819183-819500 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT74625 WP_000557292.1 NZ_CP020407:818922-819164 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT74625 NZ_CP020407:818922-819164 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References