Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 466558..467117 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ80_RS17130 Protein ID WP_000578476.1
Coordinates 466558..466836 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ80_RS17135 Protein ID WP_000381183.1
Coordinates 466833..467117 (-) Length 95 a.a.

Genomic Context

ASZ80_RS17080ASZ80_RS17085ASZ80_RS17095ASZ80_RS17100ASZ80_RS20705ASZ80_RS17105ASZ80_RS17110ASZ80_RS20710ASZ80_RS17125ASZ80_RS17140ASZ80_RS17145ASZ80_RS17160ASZ80_RS17130ASZ80_RS17135
Location: 461858..462295 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 462359..462577 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 462752..463624 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 463774..464373 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 464430..464534 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 464565..464834 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 464828..465349 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 465648..465773 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 466024..466419 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 467311..467826 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 468010..468423 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 468978..470155 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 466558..466836 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 466833..467117 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS17080461858..462295+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ80_RS17085462359..462577+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ80_RS17095462752..463624+873WP_000254716.1DUF3800 domain-containing protein-
ASZ80_RS17100463774..464373+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ80_RS20705464430..464534+105WP_099607150.1acetyltransferase-
ASZ80_RS17105464565..464834+270WP_001114075.1DUF4160 domain-containing protein-
ASZ80_RS17110464828..465349+522WP_000921691.1DUF2442 domain-containing protein-
ASZ80_RS20710465648..465773+126WP_001905700.1DUF645 family protein-
ASZ80_RS17125466024..466419+396WP_001000867.1hypothetical protein-
ASZ80_RS17130466558..466836-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ80_RS17135466833..467117-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ80_RS17140467311..467826+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ80_RS17145468010..468423+414WP_000049420.1VOC family protein-
ASZ80_RS17160468978..470155+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136
flankIS/Tn--461858..462295437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58235 WP_000578476.1 NZ_CP013302:c466836-466558 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58235 NZ_CP013302:c466836-466558 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58235 WP_000381183.1 NZ_CP013302:c467117-466833 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58235 NZ_CP013302:c467117-466833 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References