Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 430726..431130 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag O3Y_RS16270 Protein ID WP_001114075.1
Coordinates 430861..431130 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag O3Y_RS20350 Protein ID WP_099607150.1
Coordinates 430726..430830 (+) Length 35 a.a.

Genomic Context

O3Y_RS16235O3Y_RS16240O3Y_RS16245O3Y_RS16250O3Y_RS16255O3Y_RS16260O3Y_RS16265O3Y_RS20350O3Y_RS16270O3Y_RS16275O3Y_RS20355O3Y_RS16280O3Y_RS16295O3Y_RS16300O3Y_RS16285O3Y_RS16290
Location: 426227..427144 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427301..427690 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 427826..428035 (210 bp)
Type: Others
Protein ID: Protein_464
Location: 428154..428591 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428655..428873 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429048..429920 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430070..430669 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 430726..430830 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 430861..431130 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431124..431645 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 431944..432069 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432320..432715 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 433607..434122 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434306..434719 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 432854..433132 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433129..433413 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16235426227..427144+918WP_000186333.1alpha/beta hydrolase-
O3Y_RS16240427301..427690+390WP_001081302.1hypothetical protein-
O3Y_RS16245427826..428035+210Protein_464GNAT family N-acetyltransferase-
O3Y_RS16250428154..428591+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
O3Y_RS16255428655..428873+219WP_071908318.1GNAT family N-acetyltransferase-
O3Y_RS16260429048..429920+873WP_000254716.1DUF3800 domain-containing protein-
O3Y_RS16265430070..430669+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
O3Y_RS20350430726..430830+105WP_099607150.1acetyltransferaseAntitoxin
O3Y_RS16270430861..431130+270WP_001114075.1DUF4160 domain-containing proteinToxin
O3Y_RS16275431124..431645+522WP_000921691.1DUF2442 domain-containing protein-
O3Y_RS20355431944..432069+126WP_001905700.1DUF645 family protein-
O3Y_RS16280432320..432715+396WP_001000867.1hypothetical protein-
O3Y_RS16285432854..433132-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
O3Y_RS16290433129..433413-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
O3Y_RS16295433607..434122+516WP_000343779.1GNAT family N-acetyltransferase-
O3Y_RS16300434306..434719+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--428154..428591437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T26158 WP_001114075.1 NC_016945:430861-431130 [Vibrio cholerae IEC224]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T26158 NC_016945:430861-431130 [Vibrio cholerae IEC224]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT26158 WP_099607150.1 NC_016945:430726-430830 [Vibrio cholerae IEC224]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT26158 NC_016945:430726-430830 [Vibrio cholerae IEC224]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References