26158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 430726..431130 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag O3Y_RS16270 Protein ID WP_001114075.1
Coordinates 430861..431130 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag O3Y_RS20350 Protein ID WP_099607150.1
Coordinates 430726..430830 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS16235 426227..427144 + 918 WP_000186333.1 alpha/beta hydrolase -
O3Y_RS16240 427301..427690 + 390 WP_001081302.1 hypothetical protein -
O3Y_RS16245 427826..428035 + 210 Protein_464 GNAT family N-acetyltransferase -
O3Y_RS16250 428154..428591 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
O3Y_RS16255 428655..428873 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
O3Y_RS16260 429048..429920 + 873 WP_000254716.1 DUF3800 domain-containing protein -
O3Y_RS16265 430070..430669 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
O3Y_RS20350 430726..430830 + 105 WP_099607150.1 acetyltransferase Antitoxin
O3Y_RS16270 430861..431130 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
O3Y_RS16275 431124..431645 + 522 WP_000921691.1 DUF2442 domain-containing protein -
O3Y_RS20355 431944..432069 + 126 WP_001905700.1 DUF645 family protein -
O3Y_RS16280 432320..432715 + 396 WP_001000867.1 hypothetical protein -
O3Y_RS16285 432854..433132 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
O3Y_RS16290 433129..433413 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
O3Y_RS16295 433607..434122 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
O3Y_RS16300 434306..434719 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489
flank IS/Tn - - 428154..428591 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T26158 WP_001114075.1 NC_016945:430861-431130 [Vibrio cholerae IEC224]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T26158 NC_016945:430861-431130 [Vibrio cholerae IEC224]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT26158 WP_099607150.1 NC_016945:430726-430830 [Vibrio cholerae IEC224]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT26158 NC_016945:430726-430830 [Vibrio cholerae IEC224]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References