Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 481070..481598 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag ASZ85_RS17075 Protein ID WP_000221354.1
Coordinates 481311..481598 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag ASZ85_RS17070 Protein ID WP_001250179.1
Coordinates 481070..481321 (+) Length 84 a.a.

Genomic Context

ASZ85_RS17020ASZ85_RS17025ASZ85_RS21305ASZ85_RS17045ASZ85_RS17050ASZ85_RS17055ASZ85_RS21215ASZ85_RS17065ASZ85_RS17070ASZ85_RS17075ASZ85_RS17080ASZ85_RS17090ASZ85_RS17105ASZ85_RS17110ASZ85_RS17115ASZ85_RS17120ASZ85_RS17125ASZ85_RS17040ASZ85_RS17095ASZ85_RS17100
Location: 476338..476652 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 476789..477223 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 477391..477546 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 478719..479025 (307 bp)
Type: Others
Protein ID: Protein_529
Location: 479162..479854 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 479854..480255 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 480225..480368 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 480443..480856 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 481070..481321 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 481311..481598 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 481726..482181 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 482503..482655 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 483854..484522 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 484674..484961 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 485102..485473 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 485540..485965 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 485962..486495 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 477671..478651 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 482857..483354 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 483351..483623 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS17020476338..476652+315WP_000071008.1DNA-binding transcriptional regulator-
ASZ85_RS17025476789..477223+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ85_RS21305477391..477546+156WP_000751734.1hypothetical protein-
ASZ85_RS17040477671..478651-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ85_RS17045478719..479025+307Protein_529CatB-related O-acetyltransferase-
ASZ85_RS17050479162..479854+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ85_RS17055479854..480255+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ85_RS21215480225..480368+144WP_071908341.1DUF3265 domain-containing protein-
ASZ85_RS17065480443..480856+414WP_000049417.1VOC family protein-
ASZ85_RS17070481070..481321+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ85_RS17075481311..481598+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS17080481726..482181+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ85_RS17090482503..482655+153WP_001884520.1DUF645 family protein-
ASZ85_RS17095482857..483354-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ85_RS17100483351..483623-273WP_000246253.1DUF1778 domain-containing protein-
ASZ85_RS17105483854..484522+669WP_000043871.1hypothetical protein-
ASZ85_RS17110484674..484961+288WP_000426470.1hypothetical protein-
ASZ85_RS17115485102..485473+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ85_RS17120485540..485965+426WP_001882332.1DUF1778 domain-containing protein-
ASZ85_RS17125485962..486495+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092
flankIS/Tn--477671..478651980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T58405 WP_000221354.1 NZ_CP013318:481311-481598 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T58405 NZ_CP013318:481311-481598 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT58405 WP_001250179.1 NZ_CP013318:481070-481321 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT58405 NZ_CP013318:481070-481321 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References