Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343059..343618 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag O3Y_RS15595 Protein ID WP_000578476.1
Coordinates 343059..343337 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag O3Y_RS15600 Protein ID WP_000381183.1
Coordinates 343334..343618 (-) Length 95 a.a.

Genomic Context

O3Y_RS15560O3Y_RS15565O3Y_RS15570O3Y_RS19665O3Y_RS15575O3Y_RS15580O3Y_RS15585O3Y_RS15590O3Y_RS15605O3Y_RS15610O3Y_RS15615O3Y_RS15620O3Y_RS19680O3Y_RS15625O3Y_RS15630O3Y_RS19685O3Y_RS15595O3Y_RS15600
Location: 338289..338795 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338952..339338 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 339841..340092 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340065..340214 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340361..340786 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 340992..341615 (624 bp)
Type: Others
Protein ID: WP_000247071.1
Location: 341828..342307 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 342495..342908 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 343813..344328 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344393..344989 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345381..345563 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 345763..346236 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346251..346343 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 346385..347011 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347134..347832 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 347842..347952 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 343059..343337 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343334..343618 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS15560338289..338795+507WP_000393074.1hypothetical protein-
O3Y_RS15565338952..339338+387WP_000703163.1VOC family protein-
O3Y_RS15570339841..340092+252WP_001890111.1TIGR03643 family protein-
O3Y_RS19665340065..340214+150WP_071908333.1DUF3265 domain-containing protein-
O3Y_RS15575340361..340786+426WP_000415750.1hypothetical protein-
O3Y_RS15580340992..341615+624WP_000247071.1DUF1349 domain-containing protein-
O3Y_RS15585341828..342307+480WP_000009888.1lecithin retinol acyltransferase family protein-
O3Y_RS15590342495..342908+414WP_000049420.1VOC family protein-
O3Y_RS15595343059..343337-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
O3Y_RS15600343334..343618-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
O3Y_RS15605343813..344328+516WP_001201520.1lipocalin family protein-
O3Y_RS15610344393..344989+597WP_000255434.1hypothetical protein-
O3Y_RS15615345381..345563+183WP_000923182.1DUF645 family protein-
O3Y_RS15620345763..346236+474WP_001161076.1GrpB family protein-
O3Y_RS19680346251..346343+93WP_014378730.1DUF3265 domain-containing protein-
O3Y_RS15625346385..347011+627WP_000365424.1LysE family translocator-
O3Y_RS15630347134..347832+699WP_001890502.1hypothetical protein-
O3Y_RS19685347842..347952+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T26147 WP_000578476.1 NC_016945:c343337-343059 [Vibrio cholerae IEC224]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T26147 NC_016945:c343337-343059 [Vibrio cholerae IEC224]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT26147 WP_000381183.1 NC_016945:c343618-343334 [Vibrio cholerae IEC224]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT26147 NC_016945:c343618-343334 [Vibrio cholerae IEC224]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References