26147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343059..343618 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag O3Y_RS15595 Protein ID WP_000578476.1
Coordinates 343059..343337 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag O3Y_RS15600 Protein ID WP_000381183.1
Coordinates 343334..343618 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15560 338289..338795 + 507 WP_000393074.1 hypothetical protein -
O3Y_RS15565 338952..339338 + 387 WP_000703163.1 VOC family protein -
O3Y_RS15570 339841..340092 + 252 WP_001890111.1 TIGR03643 family protein -
O3Y_RS19665 340065..340214 + 150 WP_071908333.1 DUF3265 domain-containing protein -
O3Y_RS15575 340361..340786 + 426 WP_000415750.1 hypothetical protein -
O3Y_RS15580 340992..341615 + 624 WP_000247071.1 DUF1349 domain-containing protein -
O3Y_RS15585 341828..342307 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
O3Y_RS15590 342495..342908 + 414 WP_000049420.1 VOC family protein -
O3Y_RS15595 343059..343337 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
O3Y_RS15600 343334..343618 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O3Y_RS15605 343813..344328 + 516 WP_001201520.1 lipocalin family protein -
O3Y_RS15610 344393..344989 + 597 WP_000255434.1 hypothetical protein -
O3Y_RS15615 345381..345563 + 183 WP_000923182.1 DUF645 family protein -
O3Y_RS15620 345763..346236 + 474 WP_001161076.1 GrpB family protein -
O3Y_RS19680 346251..346343 + 93 WP_014378730.1 DUF3265 domain-containing protein -
O3Y_RS15625 346385..347011 + 627 WP_000365424.1 LysE family translocator -
O3Y_RS15630 347134..347832 + 699 WP_001890502.1 hypothetical protein -
O3Y_RS19685 347842..347952 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T26147 WP_000578476.1 NC_016945:c343337-343059 [Vibrio cholerae IEC224]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T26147 NC_016945:c343337-343059 [Vibrio cholerae IEC224]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT26147 WP_000381183.1 NC_016945:c343618-343334 [Vibrio cholerae IEC224]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT26147 NC_016945:c343618-343334 [Vibrio cholerae IEC224]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References