145815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 420402..420930 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GTF72_RS16045 Protein ID WP_000221354.1
Coordinates 420643..420930 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GTF72_RS16040 Protein ID WP_001250179.1
Coordinates 420402..420653 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15995 415670..415984 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
GTF72_RS16000 416121..416555 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GTF72_RS16005 416723..416878 + 156 WP_000751734.1 hypothetical protein -
GTF72_RS16010 417003..417983 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GTF72_RS16015 418051..418323 + 273 Protein_451 CatB-related O-acetyltransferase -
GTF72_RS16020 418494..419186 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GTF72_RS16025 419186..419587 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GTF72_RS16030 419557..419700 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GTF72_RS16035 419775..420188 + 414 WP_000049417.1 VOC family protein -
GTF72_RS16040 420402..420653 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS16045 420643..420930 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS16050 421058..421513 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF72_RS16055 421835..421987 + 153 WP_001884520.1 DUF645 family protein -
GTF72_RS16060 422189..422686 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF72_RS16065 422683..422955 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF72_RS16070 423186..423854 + 669 WP_000043871.1 hypothetical protein -
GTF72_RS16075 424006..424293 + 288 WP_000426470.1 hypothetical protein -
GTF72_RS16080 424434..424805 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF72_RS16085 424872..425297 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF72_RS16090 425294..425827 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804
flank IS/Tn - - 417003..417983 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145815 WP_000221354.1 NZ_CP047296:420643-420930 [Vibrio cholerae C6706]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145815 NZ_CP062700:3031560-3031667 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145815 WP_001250179.1 NZ_CP047296:420402-420653 [Vibrio cholerae C6706]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145815 NZ_CP062700:c3031512-3031453 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References