Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 420402..420930 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GTF72_RS16045 Protein ID WP_000221354.1
Coordinates 420643..420930 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GTF72_RS16040 Protein ID WP_001250179.1
Coordinates 420402..420653 (+) Length 84 a.a.

Genomic Context

GTF72_RS15995GTF72_RS16000GTF72_RS16005GTF72_RS16015GTF72_RS16020GTF72_RS16025GTF72_RS16030GTF72_RS16035GTF72_RS16040GTF72_RS16045GTF72_RS16050GTF72_RS16055GTF72_RS16070GTF72_RS16075GTF72_RS16080GTF72_RS16085GTF72_RS16090GTF72_RS16010GTF72_RS16060GTF72_RS16065
Location: 415670..415984 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 416121..416555 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416723..416878 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418051..418323 (273 bp)
Type: Others
Protein ID: Protein_451
Location: 418494..419186 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419186..419587 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419557..419700 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419775..420188 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420402..420653 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 420643..420930 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 421058..421513 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421835..421987 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423186..423854 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424006..424293 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424434..424805 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424872..425297 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425294..425827 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 417003..417983 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 422189..422686 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422683..422955 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15995415670..415984+315WP_000071008.1DNA-binding transcriptional regulator-
GTF72_RS16000416121..416555+435WP_000256036.1GNAT family N-acetyltransferase-
GTF72_RS16005416723..416878+156WP_000751734.1hypothetical protein-
GTF72_RS16010417003..417983-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTF72_RS16015418051..418323+273Protein_451CatB-related O-acetyltransferase-
GTF72_RS16020418494..419186+693WP_001047169.1GNAT family N-acetyltransferase-
GTF72_RS16025419186..419587+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF72_RS16030419557..419700+144WP_071908341.1DUF3265 domain-containing protein-
GTF72_RS16035419775..420188+414WP_000049417.1VOC family protein-
GTF72_RS16040420402..420653+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF72_RS16045420643..420930+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS16050421058..421513+456WP_001245327.1GNAT family N-acetyltransferase-
GTF72_RS16055421835..421987+153WP_001884520.1DUF645 family protein-
GTF72_RS16060422189..422686-498WP_000982260.1GNAT family N-acetyltransferase-
GTF72_RS16065422683..422955-273WP_000246253.1DUF1778 domain-containing protein-
GTF72_RS16070423186..423854+669WP_000043871.1hypothetical protein-
GTF72_RS16075424006..424293+288WP_000426470.1hypothetical protein-
GTF72_RS16080424434..424805+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF72_RS16085424872..425297+426WP_001882332.1DUF1778 domain-containing protein-
GTF72_RS16090425294..425827+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804
flankIS/Tn--417003..417983980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145815 WP_000221354.1 NZ_CP047296:420643-420930 [Vibrio cholerae C6706]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145815 NZ_CP062700:3031560-3031667 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145815 WP_001250179.1 NZ_CP047296:420402-420653 [Vibrio cholerae C6706]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145815 NZ_CP062700:c3031512-3031453 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References