Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323545..324123 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF72_RS15150 Protein ID WP_001180243.1
Coordinates 323545..323862 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF72_RS15155 Protein ID WP_000557292.1
Coordinates 323881..324123 (-) Length 81 a.a.

Genomic Context

GTF72_RS15120GTF72_RS15125GTF72_RS15130GTF72_RS15135GTF72_RS15140GTF72_RS15145GTF72_RS15160GTF72_RS15165GTF72_RS15170GTF72_RS15180GTF72_RS15185GTF72_RS15200GTF72_RS15205GTF72_RS15210GTF72_RS15150GTF72_RS15155GTF72_RS15175GTF72_RS15190GTF72_RS15195
Location: 319069..319251 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 319605..319787 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 319982..320659 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 320821..322029 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 322191..322895 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 323053..323391 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 324367..324753 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324810..324923 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324872..325153 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 325411..325947 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326084..326599 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327908..328033 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328049..328087 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 328283..328729 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 323545..323862 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 323881..324123 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 325129..325287 (159 bp)
Type: Others
Protein ID: WP_001886450.1
Location: 326749..327246 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327243..327515 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15120319069..319251+183WP_000923340.1DUF645 family protein-
GTF72_RS15125319605..319787+183WP_000923153.1DUF645 family protein-
GTF72_RS15130319982..320659+678WP_000254617.1HNH endonuclease-
GTF72_RS15135320821..322029+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
GTF72_RS15140322191..322895+705WP_000087610.1HNH endonuclease-
GTF72_RS15145323053..323391+339WP_000713853.1hypothetical protein-
GTF72_RS15150323545..323862-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS15155323881..324123-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF72_RS15160324367..324753+387WP_001015867.1NUDIX hydrolase-
GTF72_RS15165324810..324923+114WP_001900214.1hypothetical protein-
GTF72_RS15170324872..325153+282WP_001894429.1DUF1289 domain-containing protein-
GTF72_RS15175325129..325287-159WP_001886450.1DUF1196 family protein-
GTF72_RS15180325411..325947+537WP_000469482.1GNAT family N-acetyltransferase-
GTF72_RS15185326084..326599+516WP_001201509.1lipocalin family protein-
GTF72_RS15190326749..327246-498WP_000982260.1GNAT family N-acetyltransferase-
GTF72_RS15195327243..327515-273WP_000246253.1DUF1778 domain-containing protein-
GTF72_RS15200327908..328033+126WP_001900195.1DUF645 family protein-
GTF72_RS15205328049..328087+39WP_106019118.1hypothetical protein-
GTF72_RS15210328283..328729+447WP_000006157.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145803 WP_001180243.1 NZ_CP047296:c323862-323545 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145803 NZ_CP062700:359378-359653 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145803 WP_000557292.1 NZ_CP047296:c324123-323881 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145803 NZ_CP062700:359650-360009 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ7DCR7

References