145803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323545..324123 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF72_RS15150 Protein ID WP_001180243.1
Coordinates 323545..323862 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF72_RS15155 Protein ID WP_000557292.1
Coordinates 323881..324123 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15120 319069..319251 + 183 WP_000923340.1 DUF645 family protein -
GTF72_RS15125 319605..319787 + 183 WP_000923153.1 DUF645 family protein -
GTF72_RS15130 319982..320659 + 678 WP_000254617.1 HNH endonuclease -
GTF72_RS15135 320821..322029 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GTF72_RS15140 322191..322895 + 705 WP_000087610.1 HNH endonuclease -
GTF72_RS15145 323053..323391 + 339 WP_000713853.1 hypothetical protein -
GTF72_RS15150 323545..323862 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS15155 323881..324123 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS15160 324367..324753 + 387 WP_001015867.1 NUDIX hydrolase -
GTF72_RS15165 324810..324923 + 114 WP_001900214.1 hypothetical protein -
GTF72_RS15170 324872..325153 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF72_RS15175 325129..325287 - 159 WP_001886450.1 DUF1196 family protein -
GTF72_RS15180 325411..325947 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF72_RS15185 326084..326599 + 516 WP_001201509.1 lipocalin family protein -
GTF72_RS15190 326749..327246 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF72_RS15195 327243..327515 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF72_RS15200 327908..328033 + 126 WP_001900195.1 DUF645 family protein -
GTF72_RS15205 328049..328087 + 39 WP_106019118.1 hypothetical protein -
GTF72_RS15210 328283..328729 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145803 WP_001180243.1 NZ_CP047296:c323862-323545 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145803 NZ_CP062700:359378-359653 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145803 WP_000557292.1 NZ_CP047296:c324123-323881 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145803 NZ_CP062700:359650-360009 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References