25706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 50956..51722 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag HJ37_RS14260 Protein ID WP_000982260.1
Coordinates 50956..51453 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag HJ37_RS14265 Protein ID WP_000246253.1
Coordinates 51450..51722 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14215 46399..47103 + 705 WP_000087610.1 HNH endonuclease -
HJ37_RS14220 47261..47599 + 339 WP_000713853.1 hypothetical protein -
HJ37_RS14225 47753..48070 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HJ37_RS14230 48089..48331 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HJ37_RS14235 48575..48961 + 387 WP_001015867.1 NUDIX hydrolase -
HJ37_RS19360 49018..49131 + 114 WP_001900214.1 hypothetical protein -
HJ37_RS14240 49140..49360 + 221 Protein_57 DUF1289 domain-containing protein -
HJ37_RS14250 49618..50154 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
HJ37_RS14255 50291..50806 + 516 WP_001201509.1 lipocalin family protein -
HJ37_RS14260 50956..51453 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
HJ37_RS14265 51450..51722 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
HJ37_RS19880 52115..52240 + 126 WP_001900195.1 DUF645 family protein -
HJ37_RS19885 52256..52294 + 39 WP_106019118.1 hypothetical protein -
HJ37_RS14280 52489..52935 + 447 WP_000006157.1 hypothetical protein -
HJ37_RS14285 53083..53352 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HJ37_RS14290 53345..53623 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HJ37_RS19375 53952..54188 + 237 WP_161944222.1 DUF3709 domain-containing protein -
HJ37_RS19895 54440..54646 + 207 Protein_68 DUF3709 domain-containing protein -
HJ37_RS19900 54846..54947 + 102 WP_001921603.1 hypothetical protein -
HJ37_RS14300 54937..55323 + 387 WP_000703163.1 VOC family protein -
HJ37_RS14305 55518..55769 + 252 WP_001890111.1 TIGR03643 family protein -
HJ37_RS19385 55742..55891 + 150 WP_071908333.1 DUF3265 domain-containing protein -
HJ37_RS14310 55983..56225 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T25706 WP_000982260.1 NC_016446:c51453-50956 [Vibrio cholerae O1 str. 2010EL-1786]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T25706 NC_016446:c51453-50956 [Vibrio cholerae O1 str. 2010EL-1786]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT25706 WP_000246253.1 NC_016446:c51722-51450 [Vibrio cholerae O1 str. 2010EL-1786]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT25706 NC_016446:c51722-51450 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References