Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 50956..51722 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag HJ37_RS14260 Protein ID WP_000982260.1
Coordinates 50956..51453 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag HJ37_RS14265 Protein ID WP_000246253.1
Coordinates 51450..51722 (-) Length 91 a.a.

Genomic Context

HJ37_RS14215HJ37_RS14220HJ37_RS14235HJ37_RS19360HJ37_RS14240HJ37_RS14250HJ37_RS14255HJ37_RS19880HJ37_RS19885HJ37_RS14280HJ37_RS19375HJ37_RS19895HJ37_RS19900HJ37_RS14300HJ37_RS14305HJ37_RS19385HJ37_RS14310HJ37_RS14225HJ37_RS14230HJ37_RS14260HJ37_RS14265HJ37_RS14285HJ37_RS14290
Location: 46399..47103 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 47261..47599 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 48575..48961 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 49018..49131 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49140..49360 (221 bp)
Type: Others
Protein ID: Protein_57
Location: 49618..50154 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50291..50806 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52115..52240 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52256..52294 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52489..52935 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 53952..54188 (237 bp)
Type: Others
Protein ID: WP_161944222.1
Location: 54440..54646 (207 bp)
Type: Others
Protein ID: Protein_68
Location: 54846..54947 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 54937..55323 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 55518..55769 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 55742..55891 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 55983..56225 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 47753..48070 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 48089..48331 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 50956..51453 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 51450..51722 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 53083..53352 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 53345..53623 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS1421546399..47103+705WP_000087610.1HNH endonuclease-
HJ37_RS1422047261..47599+339WP_000713853.1hypothetical protein-
HJ37_RS1422547753..48070-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
HJ37_RS1423048089..48331-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HJ37_RS1423548575..48961+387WP_001015867.1NUDIX hydrolase-
HJ37_RS1936049018..49131+114WP_001900214.1hypothetical protein-
HJ37_RS1424049140..49360+221Protein_57DUF1289 domain-containing protein-
HJ37_RS1425049618..50154+537WP_000469482.1GNAT family N-acetyltransferase-
HJ37_RS1425550291..50806+516WP_001201509.1lipocalin family protein-
HJ37_RS1426050956..51453-498WP_000982260.1GNAT family N-acetyltransferaseToxin
HJ37_RS1426551450..51722-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
HJ37_RS1988052115..52240+126WP_001900195.1DUF645 family protein-
HJ37_RS1988552256..52294+39WP_106019118.1hypothetical protein-
HJ37_RS1428052489..52935+447WP_000006157.1hypothetical protein-
HJ37_RS1428553083..53352-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
HJ37_RS1429053345..53623-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
HJ37_RS1937553952..54188+237WP_161944222.1DUF3709 domain-containing protein-
HJ37_RS1989554440..54646+207Protein_68DUF3709 domain-containing protein-
HJ37_RS1990054846..54947+102WP_001921603.1hypothetical protein-
HJ37_RS1430054937..55323+387WP_000703163.1VOC family protein-
HJ37_RS1430555518..55769+252WP_001890111.1TIGR03643 family protein-
HJ37_RS1938555742..55891+150WP_071908333.1DUF3265 domain-containing protein-
HJ37_RS1431055983..56225+243WP_000107461.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T25706 WP_000982260.1 NC_016446:c51453-50956 [Vibrio cholerae O1 str. 2010EL-1786]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T25706 NC_016446:c51453-50956 [Vibrio cholerae O1 str. 2010EL-1786]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT25706 WP_000246253.1 NC_016446:c51722-51450 [Vibrio cholerae O1 str. 2010EL-1786]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT25706 NC_016446:c51722-51450 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References