Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 420402..421495 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag N16961_RS16550 Protein ID WP_000351248.1
Coordinates 421094..421495 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N16961_RS16545 Protein ID WP_001047169.1
Coordinates 420402..421094 (+) Length 231 a.a.

Genomic Context

N16961_RS16480N16961_RS19945N16961_RS16485N16961_RS16500N16961_RS16505N16961_RS16520N16961_RS16525N16961_RS16530N16961_RS19670N16961_RS16540N16961_RS16545N16961_RS16550N16961_RS16555N16961_RS16560N16961_RS16565N16961_RS16570N16961_RS16575N16961_RS16580N16961_RS16600N16961_RS16605N16961_RS16535N16961_RS16590N16961_RS16595
Location: 415685..416062 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 416119..416233 (115 bp)
Type: Others
Protein ID: Protein_439
Location: 416182..416463 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 416629..416742 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 416691..416918 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 417259..417591 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 417578..417892 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 418029..418463 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 418631..418786 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 419959..420265 (307 bp)
Type: Others
Protein ID: Protein_448
Location: 420402..421094 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 421094..421495 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 421465..421608 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 421683..422096 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 422310..422561 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 422551..422838 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 422966..423421 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 423743..423895 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 425094..425762 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 425914..426201 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 418911..419891 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 424097..424594 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 424591..424863 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS16480415685..416062+378WP_000411109.1hypothetical protein-
N16961_RS19945416119..416233+115Protein_439acetyltransferase-
N16961_RS16485416182..416463+282WP_001894453.1DUF1289 domain-containing protein-
N16961_RS16500416629..416742+114WP_001889158.1hypothetical protein-
N16961_RS16505416691..416918+228WP_001894457.1DUF1289 domain-containing protein-
N16961_RS16520417259..417591+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
N16961_RS16525417578..417892+315WP_000071008.1DNA-binding transcriptional regulator-
N16961_RS16530418029..418463+435WP_000256036.1GNAT family N-acetyltransferase-
N16961_RS19670418631..418786+156WP_000751734.1hypothetical protein-
N16961_RS16535418911..419891-981WP_000019370.1IS5-like element ISVch5 family transposase-
N16961_RS16540419959..420265+307Protein_448CatB-related O-acetyltransferase-
N16961_RS16545420402..421094+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
N16961_RS16550421094..421495+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
N16961_RS16555421465..421608+144WP_071908341.1DUF3265 domain-containing protein-
N16961_RS16560421683..422096+414WP_000049417.1VOC family protein-
N16961_RS16565422310..422561+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N16961_RS16570422551..422838+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
N16961_RS16575422966..423421+456WP_001245327.1GNAT family N-acetyltransferase-
N16961_RS16580423743..423895+153WP_001884520.1DUF645 family protein-
N16961_RS16590424097..424594-498WP_000982260.1GNAT family N-acetyltransferase-
N16961_RS16595424591..424863-273WP_000246253.1DUF1778 domain-containing protein-
N16961_RS16600425094..425762+669WP_000043871.1hypothetical protein-
N16961_RS16605425914..426201+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--418911..419891980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T104257 WP_000351248.1 NZ_CP028828:421094-421495 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T104257 NZ_CP028828:421094-421495 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT104257 WP_001047169.1 NZ_CP028828:420402-421094 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT104257 NZ_CP028828:420402-421094 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References