294360

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 958599..959137 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag DG247_RS18945 Protein ID WP_000802136.1
Coordinates 958838..959137 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag DG247_RS18940 Protein ID WP_001107719.1
Coordinates 958599..958841 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG247_RS18885 954015..954155 - 141 WP_001883049.1 DUF3265 domain-containing protein -
DG247_RS18890 954121..955056 - 936 WP_000051985.1 restriction endonuclease -
DG247_RS18895 955337..955936 - 600 WP_000429495.1 hypothetical protein -
DG247_RS18905 956091..956357 - 267 WP_000937852.1 hypothetical protein -
DG247_RS18915 956571..957254 - 684 WP_000877436.1 hypothetical protein -
DG247_RS18925 957678..957770 - 93 WP_014164112.1 DUF3265 domain-containing protein -
DG247_RS18930 957792..958370 - 579 WP_000110120.1 hypothetical protein -
DG247_RS18940 958599..958841 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DG247_RS18945 958838..959137 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG247_RS18950 959265..959660 - 396 WP_000870857.1 DUF3465 domain-containing protein -
DG247_RS18955 959874..960053 - 180 WP_001883058.1 DUF645 family protein -
DG247_RS18970 960631..960741 - 111 WP_079857360.1 DUF3265 domain-containing protein -
DG247_RS18975 960751..961449 - 699 WP_001890502.1 hypothetical protein -
DG247_RS18980 961572..962198 - 627 WP_000365424.1 LysE family translocator -
DG247_RS18985 962240..962332 - 93 WP_014378730.1 DUF3265 domain-containing protein -
DG247_RS18990 962347..962820 - 474 WP_001161076.1 GrpB family protein -
DG247_RS18995 963020..963202 - 183 WP_000923182.1 DUF645 family protein -
DG247_RS19840 963263..963391 - 129 WP_071908338.1 general secretion pathway protein GspI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 897525..994497 96972
inside Integron catB9 - 897901..987709 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T294360 WP_000802136.1 NZ_LT992487:958838-959137 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT294360 WP_001107719.1 NZ_LT992487:958599-958841 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References