Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 418215..418743 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VCA1552_RS16780 Protein ID WP_000221354.1
Coordinates 418456..418743 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VCA1552_RS16775 Protein ID WP_001250179.1
Coordinates 418215..418466 (+) Length 84 a.a.

Genomic Context

VCA1552_RS16735VCA1552_RS16740VCA1552_RS19910VCA1552_RS16750VCA1552_RS16755VCA1552_RS16760VCA1552_RS16765VCA1552_RS16770VCA1552_RS16775VCA1552_RS16780VCA1552_RS16785VCA1552_RS16790VCA1552_RS16810VCA1552_RS16815VCA1552_RS16820VCA1552_RS20040VCA1552_RS16830VCA1552_RS16745VCA1552_RS16800VCA1552_RS16805
Location: 413483..413797 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413934..414368 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 414536..414691 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415864..416136 (273 bp)
Type: Others
Protein ID: Protein_443
Location: 416307..416999 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416999..417400 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 417370..417513 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 417588..418001 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 418215..418466 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 418456..418743 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 418871..419326 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419648..419800 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420999..421667 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421819..422106 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 422247..422618 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422685..423110 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 423107..423640 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 414816..415796 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 420002..420499 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 420496..420768 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS16735413483..413797+315WP_000071008.1DNA-binding transcriptional regulator-
VCA1552_RS16740413934..414368+435WP_000256036.1GNAT family N-acetyltransferase-
VCA1552_RS19910414536..414691+156WP_000751734.1hypothetical protein-
VCA1552_RS16745414816..415796-981WP_000019370.1IS5-like element ISVch5 family transposase-
VCA1552_RS16750415864..416136+273Protein_443CatB-related O-acetyltransferase-
VCA1552_RS16755416307..416999+693WP_001047169.1GNAT family N-acetyltransferase-
VCA1552_RS16760416999..417400+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCA1552_RS16765417370..417513+144WP_071908341.1DUF3265 domain-containing protein-
VCA1552_RS16770417588..418001+414WP_000049417.1VOC family protein-
VCA1552_RS16775418215..418466+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCA1552_RS16780418456..418743+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16785418871..419326+456WP_001245327.1GNAT family N-acetyltransferase-
VCA1552_RS16790419648..419800+153WP_001884520.1DUF645 family protein-
VCA1552_RS16800420002..420499-498WP_000982260.1GNAT family N-acetyltransferase-
VCA1552_RS16805420496..420768-273WP_000246253.1DUF1778 domain-containing protein-
VCA1552_RS16810420999..421667+669WP_000043871.1hypothetical protein-
VCA1552_RS16815421819..422106+288WP_000426470.1hypothetical protein-
VCA1552_RS16820422247..422618+372WP_001164080.1nucleotide pyrophosphohydrolase-
VCA1552_RS20040422685..423110+426WP_001882332.1DUF1778 domain-containing protein-
VCA1552_RS16830423107..423640+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805
flankIS/Tn--414816..415796980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T88998 WP_000221354.1 NZ_CP024868:418456-418743 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T88998 NZ_CP024868:418456-418743 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT88998 WP_001250179.1 NZ_CP024868:418215-418466 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT88998 NZ_CP024868:418215-418466 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References