88998

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 418215..418743 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VCA1552_RS16780 Protein ID WP_000221354.1
Coordinates 418456..418743 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VCA1552_RS16775 Protein ID WP_001250179.1
Coordinates 418215..418466 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS16735 413483..413797 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
VCA1552_RS16740 413934..414368 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
VCA1552_RS19910 414536..414691 + 156 WP_000751734.1 hypothetical protein -
VCA1552_RS16745 414816..415796 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
VCA1552_RS16750 415864..416136 + 273 Protein_443 CatB-related O-acetyltransferase -
VCA1552_RS16755 416307..416999 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
VCA1552_RS16760 416999..417400 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
VCA1552_RS16765 417370..417513 + 144 WP_071908341.1 DUF3265 domain-containing protein -
VCA1552_RS16770 417588..418001 + 414 WP_000049417.1 VOC family protein -
VCA1552_RS16775 418215..418466 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCA1552_RS16780 418456..418743 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS16785 418871..419326 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
VCA1552_RS16790 419648..419800 + 153 WP_001884520.1 DUF645 family protein -
VCA1552_RS16800 420002..420499 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCA1552_RS16805 420496..420768 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCA1552_RS16810 420999..421667 + 669 WP_000043871.1 hypothetical protein -
VCA1552_RS16815 421819..422106 + 288 WP_000426470.1 hypothetical protein -
VCA1552_RS16820 422247..422618 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VCA1552_RS20040 422685..423110 + 426 WP_001882332.1 DUF1778 domain-containing protein -
VCA1552_RS16830 423107..423640 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805
flank IS/Tn - - 414816..415796 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T88998 WP_000221354.1 NZ_CP024868:418456-418743 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T88998 NZ_CP024868:418456-418743 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT88998 WP_001250179.1 NZ_CP024868:418215-418466 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT88998 NZ_CP024868:418215-418466 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References