Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 405171..405955 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag IR04_RS02085 Protein ID WP_001114075.1
Coordinates 405171..405440 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag IR04_RS02090 Protein ID WP_000921691.1
Coordinates 405434..405955 (+) Length 174 a.a.

Genomic Context

IR04_RS02050IR04_RS02055IR04_RS02060IR04_RS02065IR04_RS02070IR04_RS02075IR04_RS02080IR04_RS20045IR04_RS02085IR04_RS02090IR04_RS20050IR04_RS02095IR04_RS02110IR04_RS02115IR04_RS02125IR04_RS02100IR04_RS02105
Location: 400537..401454 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 401611..402000 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 402136..402345 (210 bp)
Type: Others
Protein ID: Protein_424
Location: 402464..402901 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402965..403183 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 403358..404230 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 404380..404979 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 405036..405140 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 405171..405440 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 405434..405955 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 406254..406379 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 406630..407025 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 407917..408432 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 408616..409029 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 409584..410761 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 407164..407442 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 407439..407723 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS02050400537..401454+918WP_000186333.1alpha/beta hydrolase-
IR04_RS02055401611..402000+390WP_001081302.1hypothetical protein-
IR04_RS02060402136..402345+210Protein_424GNAT family N-acetyltransferase-
IR04_RS02065402464..402901+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
IR04_RS02070402965..403183+219WP_071908318.1GNAT family N-acetyltransferase-
IR04_RS02075403358..404230+873WP_000254716.1DUF3800 domain-containing protein-
IR04_RS02080404380..404979+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
IR04_RS20045405036..405140+105WP_099607150.1acetyltransferase-
IR04_RS02085405171..405440+270WP_001114075.1DUF4160 domain-containing proteinToxin
IR04_RS02090405434..405955+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
IR04_RS20050406254..406379+126WP_001905700.1DUF645 family protein-
IR04_RS02095406630..407025+396WP_001000867.1hypothetical protein-
IR04_RS02100407164..407442-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
IR04_RS02105407439..407723-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
IR04_RS02110407917..408432+516WP_000343779.1GNAT family N-acetyltransferase-
IR04_RS02115408616..409029+414WP_000049420.1VOC family protein-
IR04_RS02125409584..410761+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736
flankIS/Tn--402464..402901437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T48161 WP_001114075.1 NZ_CP009041:405171-405440 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T48161 NZ_CP009041:405171-405440 [Vibrio cholerae O1 biovar El Tor]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT48161 WP_000921691.1 NZ_CP009041:405434-405955 [Vibrio cholerae O1 biovar El Tor]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT48161 NZ_CP009041:405434-405955 [Vibrio cholerae O1 biovar El Tor]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References