Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 435345..435904 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag N16961_RS16705 Protein ID WP_000578476.1
Coordinates 435345..435623 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag N16961_RS16710 Protein ID WP_000381183.1
Coordinates 435620..435904 (-) Length 95 a.a.

Genomic Context

N16961_RS16655N16961_RS16660N16961_RS16665N16961_RS16670N16961_RS16675N16961_RS16680N16961_RS16685N16961_RS16690N16961_RS16700N16961_RS16715N16961_RS16725N16961_RS16740N16961_RS16705N16961_RS16710
Location: 430645..431082 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 431146..431364 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 431539..432411 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 432561..433160 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 433217..433321 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 433352..433621 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 433615..434136 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 434435..434560 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 434811..435206 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 436098..436613 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 436797..437210 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 437765..438942 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 435345..435623 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 435620..435904 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS16655430645..431082+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N16961_RS16660431146..431364+219WP_071908318.1GNAT family N-acetyltransferase-
N16961_RS16665431539..432411+873WP_000254716.1DUF3800 domain-containing protein-
N16961_RS16670432561..433160+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
N16961_RS16675433217..433321+105WP_099607150.1acetyltransferase-
N16961_RS16680433352..433621+270WP_001114075.1DUF4160 domain-containing protein-
N16961_RS16685433615..434136+522WP_000921691.1DUF2442 domain-containing protein-
N16961_RS16690434435..434560+126WP_001905700.1DUF645 family protein-
N16961_RS16700434811..435206+396WP_001000867.1hypothetical protein-
N16961_RS16705435345..435623-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
N16961_RS16710435620..435904-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
N16961_RS16715436098..436613+516WP_000343779.1GNAT family N-acetyltransferase-
N16961_RS16725436797..437210+414WP_000049420.1VOC family protein-
N16961_RS16740437765..438942+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--430645..431082437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T104264 WP_000578476.1 NZ_CP028828:c435623-435345 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T104264 NZ_CP028828:c435623-435345 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT104264 WP_000381183.1 NZ_CP028828:c435904-435620 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT104264 NZ_CP028828:c435904-435620 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References