Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 325524..326290 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name - Uniprot ID A0A233HKB4
Locus tag ASZ80_RS15705 Protein ID WP_000982256.1
Coordinates 325524..326021 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ80_RS15710 Protein ID WP_000246254.1
Coordinates 326018..326290 (-) Length 91 a.a.

Genomic Context

ASZ80_RS15670ASZ80_RS15675ASZ80_RS20930ASZ80_RS15680ASZ80_RS21035ASZ80_RS15690ASZ80_RS20375ASZ80_RS15700ASZ80_RS15715ASZ80_RS15720ASZ80_RS15730ASZ80_RS15735ASZ80_RS15740ASZ80_RS15745ASZ80_RS20940ASZ80_RS15750ASZ80_RS15760ASZ80_RS15705ASZ80_RS15710
Location: 320924..321463 (540 bp)
Type: Others
Protein ID: WP_053035032.1
Location: 321598..322023 (426 bp)
Type: Others
Protein ID: WP_000693748.1
Location: 322080..322190 (111 bp)
Type: Others
Protein ID: WP_106746893.1
Location: 322177..322536 (360 bp)
Type: Others
Protein ID: WP_001071527.1
Location: 322678..323111 (434 bp)
Type: Others
Protein ID: Protein_277
Location: 323248..324174 (927 bp)
Type: Others
Protein ID: WP_000377813.1
Location: 324497..324650 (154 bp)
Type: Others
Protein ID: Protein_279
Location: 324879..325382 (504 bp)
Type: Others
Protein ID: WP_001158950.1
Location: 326678..326845 (168 bp)
Type: Others
Protein ID: WP_053035038.1
Location: 327053..327400 (348 bp)
Type: Others
Protein ID: WP_000933413.1
Location: 328085..328267 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 328482..329021 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 329144..329659 (516 bp)
Type: Others
Protein ID: WP_000090011.1
Location: 329794..330330 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 330449..330610 (162 bp)
Type: Others
Protein ID: WP_000481782.1
Location: 330799..330909 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 331122..331274 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 325524..326021 (498 bp)
Type: Toxin
Protein ID: WP_000982256.1
Location: 326018..326290 (273 bp)
Type: Antitoxin
Protein ID: WP_000246254.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS15670320924..321463+540WP_053035032.1phosphoglycerate mutase family protein-
ASZ80_RS15675321598..322023+426WP_000693748.1hypothetical protein-
ASZ80_RS20930322080..322190+111WP_106746893.1iron transporter-
ASZ80_RS15680322177..322536+360WP_001071527.1VOC family protein-
ASZ80_RS21035322678..323111+434Protein_277GNAT family N-acetyltransferase-
ASZ80_RS15690323248..324174+927WP_000377813.1hypothetical protein-
ASZ80_RS20375324497..324650+154Protein_279DUF645 family protein-
ASZ80_RS15700324879..325382+504WP_001158950.1DinB family protein-
ASZ80_RS15705325524..326021-498WP_000982256.1GNAT family N-acetyltransferaseToxin
ASZ80_RS15710326018..326290-273WP_000246254.1DUF1778 domain-containing proteinAntitoxin
ASZ80_RS15715326678..326845+168WP_053035038.1DUF645 family protein-
ASZ80_RS15720327053..327400+348WP_000933413.1hypothetical protein-
ASZ80_RS15730328085..328267+183WP_000923340.1DUF645 family protein-
ASZ80_RS15735328482..329021+540WP_000099372.1hypothetical protein-
ASZ80_RS15740329144..329659+516WP_000090011.1hypothetical protein-
ASZ80_RS15745329794..330330+537WP_000644491.1nucleotidyltransferase family protein-
ASZ80_RS20940330449..330610+162WP_000481782.1hypothetical protein-
ASZ80_RS15750330799..330909+111WP_071908335.1DUF3265 domain-containing protein-
ASZ80_RS15760331122..331274+153WP_001884520.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18539.23 Da        Isoelectric Point: 8.7753

>T58213 WP_000982256.1 NZ_CP013302:c326021-325524 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58213 NZ_CP013302:c326021-325524 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCATTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTGATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCTGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT58213 WP_000246254.1 NZ_CP013302:c326290-326018 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58213 NZ_CP013302:c326290-326018 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A233HKB4

Antitoxin

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Source
ID
Structure
No matching records found

References