Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 338286..338824 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag LVJ30_RS15430 Protein ID WP_000802136.1
Coordinates 338286..338585 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag LVJ30_RS15435 Protein ID WP_001107719.1
Coordinates 338582..338824 (-) Length 81 a.a.

Genomic Context

LVJ30_RS15380LVJ30_RS15385LVJ30_RS15390LVJ30_RS15395LVJ30_RS15400LVJ30_RS15405LVJ30_RS15410LVJ30_RS15415LVJ30_RS15420LVJ30_RS15425LVJ30_RS15440LVJ30_RS15445LVJ30_RS15450LVJ30_RS15455LVJ30_RS15460LVJ30_RS15465LVJ30_RS15470LVJ30_RS15430LVJ30_RS15435
Location: 333926..334042 (117 bp)
Type: Others
Protein ID: WP_086010881.1
Location: 334032..334160 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 334221..334403 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 334603..335076 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 335091..335183 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 335225..335851 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 335974..336672 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 336703..336792 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 337370..337549 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 337763..338158 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 339053..339631 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 339653..339745 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 340169..340852 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 341066..341332 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 341487..342086 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 342367..343302 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 343268..343408 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 338286..338585 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 338582..338824 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15380 (LVJ30_15385)333926..334042+117WP_086010881.1DUF3265 domain-containing protein-
LVJ30_RS15385 (LVJ30_15390)334032..334160+129WP_071908338.1general secretion pathway protein GspI-
LVJ30_RS15390 (LVJ30_15395)334221..334403+183WP_000923182.1DUF645 family protein-
LVJ30_RS15395 (LVJ30_15400)334603..335076+474WP_001161076.1GrpB family protein-
LVJ30_RS15400 (LVJ30_15405)335091..335183+93WP_014378730.1DUF3265 domain-containing protein-
LVJ30_RS15405 (LVJ30_15410)335225..335851+627WP_000365424.1LysE family translocator-
LVJ30_RS15410 (LVJ30_15415)335974..336672+699WP_001890502.1hypothetical protein-
LVJ30_RS15415 (LVJ30_15420)336703..336792+90WP_072606010.1DUF3265 domain-containing protein-
LVJ30_RS15420 (LVJ30_15425)337370..337549+180WP_001883058.1DUF645 family protein-
LVJ30_RS15425 (LVJ30_15430)337763..338158+396WP_000870857.1DUF3465 domain-containing protein-
LVJ30_RS15430 (LVJ30_15435)338286..338585-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15435 (LVJ30_15440)338582..338824-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
LVJ30_RS15440 (LVJ30_15445)339053..339631+579WP_000110120.1hypothetical protein-
LVJ30_RS15445 (LVJ30_15450)339653..339745+93WP_014164112.1DUF3265 domain-containing protein-
LVJ30_RS15450 (LVJ30_15455)340169..340852+684WP_000877436.1hypothetical protein-
LVJ30_RS15455 (LVJ30_15460)341066..341332+267WP_000937852.1hypothetical protein-
LVJ30_RS15460 (LVJ30_15465)341487..342086+600WP_000429495.1DUF6338 family protein-
LVJ30_RS15465 (LVJ30_15470)342367..343302+936WP_000051985.1restriction endonuclease-
LVJ30_RS15470 (LVJ30_15475)343268..343408+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T230519 WP_000802136.1 NZ_CP090379:c338585-338286 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T230519 NZ_CP124916:c2658201-2658100 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT230519 WP_001107719.1 NZ_CP090379:c338824-338582 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT230519 NZ_CP124916:2657976-2658155 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References