Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 340805..341364 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C1H56_RS15930 Protein ID WP_000578476.1
Coordinates 340805..341083 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C1H56_RS15935 Protein ID WP_000381183.1
Coordinates 341080..341364 (-) Length 95 a.a.

Genomic Context

C1H56_RS15880C1H56_RS15885C1H56_RS15890C1H56_RS15895C1H56_RS15900C1H56_RS15905C1H56_RS15910C1H56_RS15915C1H56_RS15925C1H56_RS15940C1H56_RS15945C1H56_RS15955C1H56_RS15960C1H56_RS15965C1H56_RS15970C1H56_RS15975C1H56_RS15980C1H56_RS15930C1H56_RS15935
Location: 335842..336075 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 336343..336849 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337006..337392 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 337587..337838 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 337811..337960 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 338107..338532 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 338738..339361 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 339574..340053 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 340241..340654 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 341559..342074 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 342139..342735 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 343127..343309 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 343509..343982 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 343979..344089 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 344131..344757 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 344880..345578 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 345582..345698 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 340805..341083 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 341080..341364 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS15880335842..336075+234WP_001890112.1DUF3709 domain-containing protein-
C1H56_RS15885336343..336849+507WP_000393074.1hypothetical protein-
C1H56_RS15890337006..337392+387WP_000703163.1VOC family protein-
C1H56_RS15895337587..337838+252WP_001890111.1TIGR03643 family protein-
C1H56_RS15900337811..337960+150WP_071908333.1DUF3265 domain-containing protein-
C1H56_RS15905338107..338532+426WP_000415750.1hypothetical protein-
C1H56_RS15910338738..339361+624WP_000247070.1DUF1349 domain-containing protein-
C1H56_RS15915339574..340053+480WP_000009888.1lecithin retinol acyltransferase family protein-
C1H56_RS15925340241..340654+414WP_000049420.1VOC family protein-
C1H56_RS15930340805..341083-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
C1H56_RS15935341080..341364-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
C1H56_RS15940341559..342074+516WP_001201520.1lipocalin family protein-
C1H56_RS15945342139..342735+597WP_000255434.1hypothetical protein-
C1H56_RS15955343127..343309+183WP_000923182.1DUF645 family protein-
C1H56_RS15960343509..343982+474WP_001161076.1GrpB family protein-
C1H56_RS15965343979..344089+111WP_071908312.1DUF3265 domain-containing protein-
C1H56_RS15970344131..344757+627WP_000365424.1LysE family translocator-
C1H56_RS15975344880..345578+699WP_001890502.1hypothetical protein-
C1H56_RS15980345582..345698+117WP_071908339.1DUF3265 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T92506 WP_000578476.1 NZ_CP025937:c341083-340805 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T92506 NZ_CP025937:c341083-340805 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT92506 WP_000381183.1 NZ_CP025937:c341364-341080 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT92506 NZ_CP025937:c341364-341080 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References