92506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 340805..341364 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag C1H56_RS15930 Protein ID WP_000578476.1
Coordinates 340805..341083 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag C1H56_RS15935 Protein ID WP_000381183.1
Coordinates 341080..341364 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS15880 335842..336075 + 234 WP_001890112.1 DUF3709 domain-containing protein -
C1H56_RS15885 336343..336849 + 507 WP_000393074.1 hypothetical protein -
C1H56_RS15890 337006..337392 + 387 WP_000703163.1 VOC family protein -
C1H56_RS15895 337587..337838 + 252 WP_001890111.1 TIGR03643 family protein -
C1H56_RS15900 337811..337960 + 150 WP_071908333.1 DUF3265 domain-containing protein -
C1H56_RS15905 338107..338532 + 426 WP_000415750.1 hypothetical protein -
C1H56_RS15910 338738..339361 + 624 WP_000247070.1 DUF1349 domain-containing protein -
C1H56_RS15915 339574..340053 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
C1H56_RS15925 340241..340654 + 414 WP_000049420.1 VOC family protein -
C1H56_RS15930 340805..341083 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C1H56_RS15935 341080..341364 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C1H56_RS15940 341559..342074 + 516 WP_001201520.1 lipocalin family protein -
C1H56_RS15945 342139..342735 + 597 WP_000255434.1 hypothetical protein -
C1H56_RS15955 343127..343309 + 183 WP_000923182.1 DUF645 family protein -
C1H56_RS15960 343509..343982 + 474 WP_001161076.1 GrpB family protein -
C1H56_RS15965 343979..344089 + 111 WP_071908312.1 DUF3265 domain-containing protein -
C1H56_RS15970 344131..344757 + 627 WP_000365424.1 LysE family translocator -
C1H56_RS15975 344880..345578 + 699 WP_001890502.1 hypothetical protein -
C1H56_RS15980 345582..345698 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T92506 WP_000578476.1 NZ_CP025937:c341083-340805 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T92506 NZ_CP025937:c341083-340805 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT92506 WP_000381183.1 NZ_CP025937:c341364-341080 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT92506 NZ_CP025937:c341364-341080 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References