230529

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 395171..395955 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag LVJ30_RS16000 Protein ID WP_001114075.1
Coordinates 395171..395440 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag LVJ30_RS16005 Protein ID WP_000921691.1
Coordinates 395434..395955 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ30_RS15960 (LVJ30_15960) 390537..391454 + 918 WP_000186333.1 alpha/beta hydrolase -
LVJ30_RS15965 (LVJ30_15965) 391611..392000 + 390 WP_001081302.1 hypothetical protein -
LVJ30_RS15970 (LVJ30_15970) 392136..392345 + 210 Protein_427 GNAT family N-acetyltransferase -
LVJ30_RS15975 (LVJ30_15975) 392464..392901 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
LVJ30_RS15980 (LVJ30_15980) 392962..393183 + 222 Protein_429 GNAT family N-acetyltransferase -
LVJ30_RS15985 (LVJ30_15985) 393358..394230 + 873 WP_000254716.1 DUF3800 domain-containing protein -
LVJ30_RS15990 (LVJ30_15990) 394380..394979 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
LVJ30_RS15995 (LVJ30_15995) 395036..395104 + 69 Protein_432 acetyltransferase -
LVJ30_RS16000 (LVJ30_16000) 395171..395440 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
LVJ30_RS16005 (LVJ30_16005) 395434..395955 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
LVJ30_RS16010 (LVJ30_16010) 396254..396379 + 126 WP_001905700.1 DUF645 family protein -
LVJ30_RS16015 (LVJ30_16015) 396630..397025 + 396 WP_001000867.1 hypothetical protein -
LVJ30_RS16020 (LVJ30_16020) 397164..397442 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
LVJ30_RS16025 (LVJ30_16025) 397439..397723 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LVJ30_RS16030 (LVJ30_16030) 397917..398432 + 516 WP_000343779.1 GNAT family protein -
LVJ30_RS16035 (LVJ30_16035) 398616..399029 + 414 WP_000049420.1 VOC family protein -
LVJ30_RS16040 (LVJ30_16040) 399584..400761 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791
flank IS/Tn - - 392464..392901 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T230529 WP_001114075.1 NZ_CP090379:395171-395440 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T230529 NZ_CP124918:c2801313-2800972 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT230529 WP_000921691.1 NZ_CP090379:395434-395955 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT230529 NZ_CP124918:c2801543-2801313 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References