74623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 785027..785555 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag A6J62_RS03720 Protein ID WP_000221352.1
Coordinates 785265..785555 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag A6J62_RS03715 Protein ID WP_000213183.1
Coordinates 785027..785275 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS03665 780066..780530 + 465 WP_000140244.1 hypothetical protein -
A6J62_RS03670 780630..781028 - 399 WP_001882293.1 hypothetical protein -
A6J62_RS03680 781184..781684 - 501 WP_000789723.1 hypothetical protein -
A6J62_RS03685 781822..782352 - 531 WP_000415563.1 hypothetical protein -
A6J62_RS03690 782503..782898 - 396 WP_000649527.1 DUF3465 domain-containing protein -
A6J62_RS03695 783106..783531 - 426 WP_000415748.1 hypothetical protein -
A6J62_RS03700 783803..784456 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
A6J62_RS03715 785027..785275 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J62_RS03720 785265..785555 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS03725 785691..786206 - 516 WP_001201528.1 lipocalin family protein -
A6J62_RS03730 786343..786819 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
A6J62_RS03735 786847..786957 - 111 WP_071917832.1 DUF3265 domain-containing protein -
A6J62_RS03740 786954..787883 - 930 WP_000335802.1 hypothetical protein -
A6J62_RS03745 788003..788449 - 447 WP_000128977.1 hypothetical protein -
A6J62_RS03750 788602..789606 - 1005 WP_000964925.1 LD-carboxypeptidase -
A6J62_RS19655 789819..789857 - 39 WP_106019119.1 hypothetical protein -
A6J62_RS19660 789873..789998 - 126 WP_001944767.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T74623 WP_000221352.1 NZ_CP020407:785265-785555 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T74623 NZ_CP020407:785265-785555 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT74623 WP_000213183.1 NZ_CP020407:785027-785275 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT74623 NZ_CP020407:785027-785275 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References