Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 785027..785555 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag A6J62_RS03720 Protein ID WP_000221352.1
Coordinates 785265..785555 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag A6J62_RS03715 Protein ID WP_000213183.1
Coordinates 785027..785275 (+) Length 83 a.a.

Genomic Context

A6J62_RS03665A6J62_RS03715A6J62_RS03720A6J62_RS03670A6J62_RS03680A6J62_RS03685A6J62_RS03690A6J62_RS03695A6J62_RS03700A6J62_RS03725A6J62_RS03730A6J62_RS03735A6J62_RS03740A6J62_RS03745A6J62_RS03750A6J62_RS19655A6J62_RS19660
Location: 780066..780530 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 785027..785275 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 785265..785555 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 780630..781028 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 781184..781684 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 781822..782352 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 782503..782898 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 783106..783531 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 783803..784456 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 785691..786206 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 786343..786819 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 786847..786957 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 786954..787883 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 788003..788449 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 788602..789606 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 789819..789857 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 789873..789998 (126 bp)
Type: Others
Protein ID: WP_001944767.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS03665780066..780530+465WP_000140244.1hypothetical protein-
A6J62_RS03670780630..781028-399WP_001882293.1hypothetical protein-
A6J62_RS03680781184..781684-501WP_000789723.1hypothetical protein-
A6J62_RS03685781822..782352-531WP_000415563.1hypothetical protein-
A6J62_RS03690782503..782898-396WP_000649527.1DUF3465 domain-containing protein-
A6J62_RS03695783106..783531-426WP_000415748.1hypothetical protein-
A6J62_RS03700783803..784456-654WP_000036957.1site-specific DNA-methyltransferase-
A6J62_RS03715785027..785275+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A6J62_RS03720785265..785555+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A6J62_RS03725785691..786206-516WP_001201528.1lipocalin family protein-
A6J62_RS03730786343..786819-477WP_001047180.1GNAT family N-acetyltransferase-
A6J62_RS03735786847..786957-111WP_071917832.1DUF3265 domain-containing protein-
A6J62_RS03740786954..787883-930WP_000335802.1hypothetical protein-
A6J62_RS03745788003..788449-447WP_000128977.1hypothetical protein-
A6J62_RS03750788602..789606-1005WP_000964925.1LD-carboxypeptidase-
A6J62_RS19655789819..789857-39WP_106019119.1hypothetical protein-
A6J62_RS19660789873..789998-126WP_001944767.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T74623 WP_000221352.1 NZ_CP020407:785265-785555 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T74623 NZ_CP020407:785265-785555 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT74623 WP_000213183.1 NZ_CP020407:785027-785275 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT74623 NZ_CP020407:785027-785275 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References