211915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 973875..974490 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag K1T75_RS18130 Protein ID WP_001162670.1
Coordinates 974203..974490 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1T75_RS18125 Protein ID WP_001232701.1
Coordinates 973875..974192 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18090 969284..969745 - 462 WP_001911752.1 lipocalin family protein -
K1T75_RS18095 969936..970412 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
K1T75_RS18885 970440..970550 - 111 WP_071917832.1 DUF3265 domain-containing protein -
K1T75_RS18100 970547..971476 - 930 WP_000335802.1 hypothetical protein -
K1T75_RS18105 971596..972042 - 447 WP_000128977.1 hypothetical protein -
K1T75_RS18110 972195..973199 - 1005 WP_000964925.1 LD-carboxypeptidase -
K1T75_RS18890 973387..973503 - 117 WP_001889170.1 hypothetical protein -
K1T75_RS18120 973466..973591 - 126 WP_001944767.1 DUF645 family protein -
K1T75_RS18895 973619..973729 - 111 Protein_877 acetyltransferase -
K1T75_RS18900 973768..973878 - 111 WP_134814058.1 DUF3265 domain-containing protein -
K1T75_RS18125 973875..974192 - 318 WP_001232701.1 HigA family addiction module antitoxin Antitoxin
K1T75_RS18130 974203..974490 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS18905 974531..974644 - 114 WP_001894955.1 hypothetical protein -
K1T75_RS18135 974757..974937 - 181 Protein_882 DUF645 family protein -
K1T75_RS18140 975362..975595 - 234 WP_032482776.1 DUF3709 domain-containing protein -
K1T75_RS18910 975616..975809 - 194 Protein_884 hypothetical protein -
K1T75_RS18145 975998..976216 - 219 WP_001917086.1 DUF3709 domain-containing protein -
K1T75_RS18915 976228..976437 - 210 WP_001900246.1 DUF3709 domain-containing protein -
K1T75_RS18150 976526..977179 - 654 WP_000226874.1 hypothetical protein -
K1T75_RS18155 977236..977745 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
K1T75_RS18160 977987..978229 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS18165 978248..978565 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS18920 978759..978911 - 153 Protein_891 DUF645 family protein -
K1T75_RS18925 978972..979147 - 176 Protein_892 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T211915 WP_001162670.1 NZ_CP080466:c974490-974203 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T211915 NZ_CP106841:c2333562-2332213 [Paenalcaligenes faecalis]
ATGGGTCGACGCTCTCACACACAGACTCTATATCTCTGGATGAATGGCTATTTCGTCGGTACATGGAGCGTACGGCCCTA
TACTGGCGATATATTGCAGTACGACGAAGGCTGGGTCGTCTCCGAGCATGGCAGGCCGCTGTCCCTCTCTCTACCATTTA
CGCCAGGCAACCCGCCGCATCGAGGCGATGCCGTCCGTACCTACTTCGAGAACCTGCTTCCAGACAGTGAGGACATCCTA
AAACGTGTCGCGCGCCGGTTTCAGGCCAGCTCGACCGGGGCATTCGCGCTGCTGGCCGAGATTGGACGGGATTGCGTGGG
GGCGCTGCAGATACTCCCTGATAATGTTCCACCCGAGGGTGTTCAAGAAGTGAGCGCAACGCCATTGACTGATGCCGAGG
TGGCCCAAGTGTTGCGAAACACCCTAGCGTCGGTATCGTTAATTCAAGGCAGTGATGATGTTGACTTTCGGATTTCCATC
GCAGGTGCGCAGGAAAAAACAGCTTTGTCATGGCTCAATGGACAGTGGTGTCTACCTCATGGCGCGACACCAACTACGCA
TATCTTCAAACTACCGCTGGGACTAGTCGGCAACCTCAGGTTCGACATGAGCGACTCAGTCGAAAACGAATGGCTATGCT
CCAAAATTCTGCACGCTTACGGCCTACCGGTGGCATCCACGCAGATCCTTGAGTTCGAGGATATGAAGGTGCTTGCCGTC
GAGCGATTCGACCGTATGTGGTGGGAAAACGAAGAAGGCAAGAGATGGCTTCTCCGTATACCTCAGGAAGACATGTGCCA
GGCAACAGGAACCCCTCCCTACCTGAAGTACGAGTCCGACGGAGGGCCTGGAGTGCGTACCATCATGAAACTGTTGGCCA
CGTCCAGAGACCCTGACCGTGACCGGCGAACTTTCTTCCAGGCCCAAGTCCTATTCTGGATGCTTAGCGCCACCGATGGC
CATGCAAAGAACTTCAGTATTTTCCTACGCCCCGAAGGAACATACGAGCTTACCCCGTTGTACGACGTGCTTTCGGCGTA
CCCGGTCATAGGTAAAGGCGCTAATCAATTATCCCCGTTTAAGGCGAAGCTGGCTATGGCGGTGCGCTCAAAGAACCCGC
ACTGGGTCATGCGAGACATCTTGCGTCGGCATTGGCTTGCTGTGGGGGCTGAGCATGGCGTTGTGGCGCCGGATGGCCGC
GGAGCGGAGGCGGTTCTTGACGATTTGGTGGCGAAGACCCCGGAAGTCGTGCGTGCAGTTCGGGCACTGCTACCCAAGAG
GTTTCCTGAACATGTAGCTGACAGCATCCTCAACGGACTACAGCTAGCAGCCAATAAATTAACCGGTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT211915 WP_001232701.1 NZ_CP080466:c974192-973875 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT211915 NZ_CP106841:c2333826-2333566 [Paenalcaligenes faecalis]
ATGACGGACTTCACTATTCGCACCGCGGACCAGCTTCCGCTAATGCTCCAAGCTTTTCGCAAGCAGGCTAACCTGACCCA
GACTGATGTGGCAATGCGCCTAGGTGTCACGCAACAGACGCTCTCTGCCTTGGAACGCAACGCAAAAAAAGTCAGTGCTG
AGCGCCTTTTGGAGCTGCTGAGTATTTTGGGTGTAGAACTGGTGCTGCGTCAGAATAGCGATGCACCCTCACCAAAACCG
TCAACCGGTTCGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2HI36

Antitoxin

Source ID Structure

References