Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 973875..974490 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag K1T75_RS18130 Protein ID WP_001162670.1
Coordinates 974203..974490 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1T75_RS18125 Protein ID WP_001232701.1
Coordinates 973875..974192 (-) Length 106 a.a.

Genomic Context

K1T75_RS18160K1T75_RS18165K1T75_RS18090K1T75_RS18095K1T75_RS18885K1T75_RS18100K1T75_RS18105K1T75_RS18110K1T75_RS18890K1T75_RS18120K1T75_RS18895K1T75_RS18900K1T75_RS18125K1T75_RS18130K1T75_RS18905K1T75_RS18135K1T75_RS18140K1T75_RS18910K1T75_RS18145K1T75_RS18915K1T75_RS18150K1T75_RS18155K1T75_RS18920K1T75_RS18925
Location: 977987..978229 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 978248..978565 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 969284..969745 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 969936..970412 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 970440..970550 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 970547..971476 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 971596..972042 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 972195..973199 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 973387..973503 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 973466..973591 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 973619..973729 (111 bp)
Type: Others
Protein ID: Protein_877
Location: 973768..973878 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 973875..974192 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 974203..974490 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 974531..974644 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 974757..974937 (181 bp)
Type: Others
Protein ID: Protein_882
Location: 975362..975595 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 975616..975809 (194 bp)
Type: Others
Protein ID: Protein_884
Location: 975998..976216 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 976228..976437 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 976526..977179 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 977236..977745 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 978759..978911 (153 bp)
Type: Others
Protein ID: Protein_891
Location: 978972..979147 (176 bp)
Type: Others
Protein ID: Protein_892
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS18090969284..969745-462WP_001911752.1lipocalin family protein-
K1T75_RS18095969936..970412-477WP_001047180.1GNAT family N-acetyltransferase-
K1T75_RS18885970440..970550-111WP_071917832.1DUF3265 domain-containing protein-
K1T75_RS18100970547..971476-930WP_000335802.1hypothetical protein-
K1T75_RS18105971596..972042-447WP_000128977.1hypothetical protein-
K1T75_RS18110972195..973199-1005WP_000964925.1LD-carboxypeptidase-
K1T75_RS18890973387..973503-117WP_001889170.1hypothetical protein-
K1T75_RS18120973466..973591-126WP_001944767.1DUF645 family protein-
K1T75_RS18895973619..973729-111Protein_877acetyltransferase-
K1T75_RS18900973768..973878-111WP_134814058.1DUF3265 domain-containing protein-
K1T75_RS18125973875..974192-318WP_001232701.1HigA family addiction module antitoxinAntitoxin
K1T75_RS18130974203..974490-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K1T75_RS18905974531..974644-114WP_001894955.1hypothetical protein-
K1T75_RS18135974757..974937-181Protein_882DUF645 family protein-
K1T75_RS18140975362..975595-234WP_032482776.1DUF3709 domain-containing protein-
K1T75_RS18910975616..975809-194Protein_884hypothetical protein-
K1T75_RS18145975998..976216-219WP_001917086.1DUF3709 domain-containing protein-
K1T75_RS18915976228..976437-210WP_001900246.1DUF3709 domain-containing protein-
K1T75_RS18150976526..977179-654WP_000226874.1hypothetical protein-
K1T75_RS18155977236..977745-510WP_000405987.1GNAT family N-acetyltransferase-
K1T75_RS18160977987..978229+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K1T75_RS18165978248..978565+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
K1T75_RS18920978759..978911-153Protein_891DUF645 family protein-
K1T75_RS18925978972..979147-176Protein_892acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T211915 WP_001162670.1 NZ_CP080466:c974490-974203 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T211915 NZ_CP106841:c2333562-2332213 [Paenalcaligenes faecalis]
ATGGGTCGACGCTCTCACACACAGACTCTATATCTCTGGATGAATGGCTATTTCGTCGGTACATGGAGCGTACGGCCCTA
TACTGGCGATATATTGCAGTACGACGAAGGCTGGGTCGTCTCCGAGCATGGCAGGCCGCTGTCCCTCTCTCTACCATTTA
CGCCAGGCAACCCGCCGCATCGAGGCGATGCCGTCCGTACCTACTTCGAGAACCTGCTTCCAGACAGTGAGGACATCCTA
AAACGTGTCGCGCGCCGGTTTCAGGCCAGCTCGACCGGGGCATTCGCGCTGCTGGCCGAGATTGGACGGGATTGCGTGGG
GGCGCTGCAGATACTCCCTGATAATGTTCCACCCGAGGGTGTTCAAGAAGTGAGCGCAACGCCATTGACTGATGCCGAGG
TGGCCCAAGTGTTGCGAAACACCCTAGCGTCGGTATCGTTAATTCAAGGCAGTGATGATGTTGACTTTCGGATTTCCATC
GCAGGTGCGCAGGAAAAAACAGCTTTGTCATGGCTCAATGGACAGTGGTGTCTACCTCATGGCGCGACACCAACTACGCA
TATCTTCAAACTACCGCTGGGACTAGTCGGCAACCTCAGGTTCGACATGAGCGACTCAGTCGAAAACGAATGGCTATGCT
CCAAAATTCTGCACGCTTACGGCCTACCGGTGGCATCCACGCAGATCCTTGAGTTCGAGGATATGAAGGTGCTTGCCGTC
GAGCGATTCGACCGTATGTGGTGGGAAAACGAAGAAGGCAAGAGATGGCTTCTCCGTATACCTCAGGAAGACATGTGCCA
GGCAACAGGAACCCCTCCCTACCTGAAGTACGAGTCCGACGGAGGGCCTGGAGTGCGTACCATCATGAAACTGTTGGCCA
CGTCCAGAGACCCTGACCGTGACCGGCGAACTTTCTTCCAGGCCCAAGTCCTATTCTGGATGCTTAGCGCCACCGATGGC
CATGCAAAGAACTTCAGTATTTTCCTACGCCCCGAAGGAACATACGAGCTTACCCCGTTGTACGACGTGCTTTCGGCGTA
CCCGGTCATAGGTAAAGGCGCTAATCAATTATCCCCGTTTAAGGCGAAGCTGGCTATGGCGGTGCGCTCAAAGAACCCGC
ACTGGGTCATGCGAGACATCTTGCGTCGGCATTGGCTTGCTGTGGGGGCTGAGCATGGCGTTGTGGCGCCGGATGGCCGC
GGAGCGGAGGCGGTTCTTGACGATTTGGTGGCGAAGACCCCGGAAGTCGTGCGTGCAGTTCGGGCACTGCTACCCAAGAG
GTTTCCTGAACATGTAGCTGACAGCATCCTCAACGGACTACAGCTAGCAGCCAATAAATTAACCGGTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT211915 WP_001232701.1 NZ_CP080466:c974192-973875 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT211915 NZ_CP106841:c2333826-2333566 [Paenalcaligenes faecalis]
ATGACGGACTTCACTATTCGCACCGCGGACCAGCTTCCGCTAATGCTCCAAGCTTTTCGCAAGCAGGCTAACCTGACCCA
GACTGATGTGGCAATGCGCCTAGGTGTCACGCAACAGACGCTCTCTGCCTTGGAACGCAACGCAAAAAAAGTCAGTGCTG
AGCGCCTTTTGGAGCTGCTGAGTATTTTGGGTGTAGAACTGGTGCTGCGTCAGAATAGCGATGCACCCTCACCAAAACCG
TCAACCGGTTCGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References