113805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 172070..172648 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag EEL44_RS01030 Protein ID WP_001180243.1
Coordinates 172331..172648 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag EEL44_RS01025 Protein ID WP_000557292.1
Coordinates 172070..172312 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS00970 167495..167533 - 39 WP_106019119.1 hypothetical protein -
EEL44_RS00975 167549..167674 - 126 WP_001944767.1 DUF645 family protein -
EEL44_RS21145 167851..167961 - 111 WP_134814058.1 DUF3265 domain-containing protein -
EEL44_RS00990 167958..168275 - 318 WP_001232701.1 HigA family addiction module antidote protein -
EEL44_RS00995 168286..168573 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
EEL44_RS01000 168840..169020 - 181 Protein_181 DUF645 family protein -
EEL44_RS01005 169445..169678 - 234 WP_032482776.1 DUF3709 domain-containing protein -
EEL44_RS01010 170081..170299 - 219 WP_001917086.1 DUF3709 domain-containing protein -
EEL44_RS01015 170609..171262 - 654 WP_000226874.1 hypothetical protein -
EEL44_RS01020 171319..171828 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
EEL44_RS01025 172070..172312 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EEL44_RS01030 172331..172648 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS21150 172842..172937 - 96 WP_001907607.1 DUF645 family protein -
EEL44_RS20965 173293..173586 - 294 WP_125460920.1 hypothetical protein -
EEL44_RS01050 173733..174080 - 348 WP_000933409.1 hypothetical protein -
EEL44_RS01055 174229..174654 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
EEL44_RS01060 174850..175029 - 180 WP_001883039.1 DUF645 family protein -
EEL44_RS01065 175326..175862 - 537 WP_000644491.1 nucleotidyltransferase family protein -
EEL44_RS01070 176006..176401 - 396 WP_000046953.1 hypothetical protein -
EEL44_RS01075 176578..176759 - 182 Protein_195 DUF645 family protein -
EEL44_RS01080 177062..177457 - 396 WP_000046952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 127139..226875 99736
- inside Genomic island catB9 - 126763..233717 106954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T113805 WP_001180243.1 NZ_CP033513:172331-172648 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T113805 NZ_CP033513:172331-172648 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT113805 WP_000557292.1 NZ_CP033513:172070-172312 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT113805 NZ_CP033513:172070-172312 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References