Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 172070..172648 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag EEL44_RS01030 Protein ID WP_001180243.1
Coordinates 172331..172648 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag EEL44_RS01025 Protein ID WP_000557292.1
Coordinates 172070..172312 (+) Length 81 a.a.

Genomic Context

EEL44_RS01025EEL44_RS01030EEL44_RS00970EEL44_RS00975EEL44_RS21145EEL44_RS00990EEL44_RS00995EEL44_RS01000EEL44_RS01005EEL44_RS01010EEL44_RS01015EEL44_RS01020EEL44_RS21150EEL44_RS20965EEL44_RS01050EEL44_RS01055EEL44_RS01060EEL44_RS01065EEL44_RS01070EEL44_RS01075EEL44_RS01080
Location: 172070..172312 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 172331..172648 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 167495..167533 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 167549..167674 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 167851..167961 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 167958..168275 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 168286..168573 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 168840..169020 (181 bp)
Type: Others
Protein ID: Protein_181
Location: 169445..169678 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 170081..170299 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 170609..171262 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 171319..171828 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 172842..172937 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 173293..173586 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 173733..174080 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 174229..174654 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 174850..175029 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 175326..175862 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 176006..176401 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 176578..176759 (182 bp)
Type: Others
Protein ID: Protein_195
Location: 177062..177457 (396 bp)
Type: Others
Protein ID: WP_000046952.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00970167495..167533-39WP_106019119.1hypothetical protein-
EEL44_RS00975167549..167674-126WP_001944767.1DUF645 family protein-
EEL44_RS21145167851..167961-111WP_134814058.1DUF3265 domain-containing protein-
EEL44_RS00990167958..168275-318WP_001232701.1HigA family addiction module antidote protein-
EEL44_RS00995168286..168573-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
EEL44_RS01000168840..169020-181Protein_181DUF645 family protein-
EEL44_RS01005169445..169678-234WP_032482776.1DUF3709 domain-containing protein-
EEL44_RS01010170081..170299-219WP_001917086.1DUF3709 domain-containing protein-
EEL44_RS01015170609..171262-654WP_000226874.1hypothetical protein-
EEL44_RS01020171319..171828-510WP_000405987.1GNAT family N-acetyltransferase-
EEL44_RS01025172070..172312+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EEL44_RS01030172331..172648+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS21150172842..172937-96WP_001907607.1DUF645 family protein-
EEL44_RS20965173293..173586-294WP_125460920.1hypothetical protein-
EEL44_RS01050173733..174080-348WP_000933409.1hypothetical protein-
EEL44_RS01055174229..174654-426WP_000403014.1GNAT family N-acetyltransferase-
EEL44_RS01060174850..175029-180WP_001883039.1DUF645 family protein-
EEL44_RS01065175326..175862-537WP_000644491.1nucleotidyltransferase family protein-
EEL44_RS01070176006..176401-396WP_000046953.1hypothetical protein-
EEL44_RS01075176578..176759-182Protein_195DUF645 family protein-
EEL44_RS01080177062..177457-396WP_000046952.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--127139..22687599736
-insideGenomic islandcatB9-126763..233717106954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T113805 WP_001180243.1 NZ_CP033513:172331-172648 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T113805 NZ_CP033513:172331-172648 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT113805 WP_000557292.1 NZ_CP033513:172070-172312 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT113805 NZ_CP033513:172070-172312 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References