Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 332541..333039 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag AN947_RS01650 Protein ID WP_000589156.1
Coordinates 332541..332807 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag AN947_RS01655 Protein ID WP_000643598.1
Coordinates 332794..333039 (+) Length 82 a.a.

Genomic Context

AN947_RS20720AN947_RS20725AN947_RS01590AN947_RS01595AN947_RS01600AN947_RS01605AN947_RS01610AN947_RS20730AN947_RS20735AN947_RS01635AN947_RS01640AN947_RS01650AN947_RS01655AN947_RS01665AN947_RS01675AN947_RS01680AN947_RS01685AN947_RS01690AN947_RS01695AN947_RS01700AN947_RS01705AN947_RS01720
Location: 327962..328168 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 328368..328469 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328459..328845 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 329040..329291 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 329264..329413 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329505..329747 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 329999..330277 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 330652..330795 (144 bp)
Type: Others
Protein ID: Protein_297
Location: 330849..330887 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 331099..331566 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 331694..332356 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 332541..332807 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 332794..333039 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 333135..333929 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 334032..334160 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 334221..334403 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 334603..335076 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 335091..335183 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 335225..335851 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 335974..336672 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 336682..336792 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 337370..337549 (180 bp)
Type: Others
Protein ID: WP_001883058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AN947_RS20720327962..328168+207Protein_290DUF3709 domain-containing protein-
AN947_RS20725328368..328469+102WP_001921603.1hypothetical protein-
AN947_RS01590328459..328845+387WP_000703163.1VOC family protein-
AN947_RS01595329040..329291+252WP_001890111.1TIGR03643 family protein-
AN947_RS01600329264..329413+150WP_071908333.1DUF3265 domain-containing protein-
AN947_RS01605329505..329747+243WP_000107461.1hypothetical protein-
AN947_RS01610329999..330277+279WP_000280324.1DUF3709 domain-containing protein-
AN947_RS20730330652..330795+144Protein_297DUF645 family protein-
AN947_RS20735330849..330887+39WP_082798268.1hypothetical protein-
AN947_RS01635331099..331566+468WP_001289288.1OsmC family protein-
AN947_RS01640331694..332356+663WP_000960654.1hypothetical protein-
AN947_RS01650332541..332807+267WP_000589156.1BrnT family toxinToxin
AN947_RS01655332794..333039+246WP_000643598.1hypothetical proteinAntitoxin
AN947_RS01665333135..333929+795WP_001911581.1hypothetical protein-
AN947_RS01675334032..334160+129WP_071908338.1general secretion pathway protein GspI-
AN947_RS01680334221..334403+183WP_000923182.1DUF645 family protein-
AN947_RS01685334603..335076+474WP_001161076.1GrpB family protein-
AN947_RS01690335091..335183+93WP_014378730.1DUF3265 domain-containing protein-
AN947_RS01695335225..335851+627WP_000365424.1LysE family translocator-
AN947_RS01700335974..336672+699WP_001890502.1hypothetical protein-
AN947_RS01705336682..336792+111WP_079857360.1DUF3265 domain-containing protein-
AN947_RS01720337370..337549+180WP_001883058.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T56912 WP_000589156.1 NZ_CP012666:332541-332807 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T56912 NZ_CP012666:332541-332807 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT56912 WP_000643598.1 NZ_CP012666:332794-333039 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT56912 NZ_CP012666:332794-333039 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References