Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 422310..422838 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag N16961_RS16570 Protein ID WP_000221354.1
Coordinates 422551..422838 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag N16961_RS16565 Protein ID WP_001250179.1
Coordinates 422310..422561 (+) Length 84 a.a.

Genomic Context

N16961_RS16525N16961_RS16530N16961_RS19670N16961_RS16540N16961_RS16545N16961_RS16550N16961_RS16555N16961_RS16560N16961_RS16565N16961_RS16570N16961_RS16575N16961_RS16580N16961_RS16600N16961_RS16605N16961_RS16610N16961_RS16615N16961_RS16620N16961_RS16535N16961_RS16590N16961_RS16595
Location: 417578..417892 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 418029..418463 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 418631..418786 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 419959..420265 (307 bp)
Type: Others
Protein ID: Protein_448
Location: 420402..421094 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 421094..421495 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 421465..421608 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 421683..422096 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 422310..422561 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 422551..422838 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 422966..423421 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 423743..423895 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 425094..425762 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 425914..426201 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 426342..426713 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 426780..427205 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 427202..427735 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 418911..419891 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 424097..424594 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 424591..424863 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS16525417578..417892+315WP_000071008.1DNA-binding transcriptional regulator-
N16961_RS16530418029..418463+435WP_000256036.1GNAT family N-acetyltransferase-
N16961_RS19670418631..418786+156WP_000751734.1hypothetical protein-
N16961_RS16535418911..419891-981WP_000019370.1IS5-like element ISVch5 family transposase-
N16961_RS16540419959..420265+307Protein_448CatB-related O-acetyltransferase-
N16961_RS16545420402..421094+693WP_001047169.1GNAT family N-acetyltransferase-
N16961_RS16550421094..421495+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
N16961_RS16555421465..421608+144WP_071908341.1DUF3265 domain-containing protein-
N16961_RS16560421683..422096+414WP_000049417.1VOC family protein-
N16961_RS16565422310..422561+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N16961_RS16570422551..422838+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS16575422966..423421+456WP_001245327.1GNAT family N-acetyltransferase-
N16961_RS16580423743..423895+153WP_001884520.1DUF645 family protein-
N16961_RS16590424097..424594-498WP_000982260.1GNAT family N-acetyltransferase-
N16961_RS16595424591..424863-273WP_000246253.1DUF1778 domain-containing protein-
N16961_RS16600425094..425762+669WP_000043871.1hypothetical protein-
N16961_RS16605425914..426201+288WP_000426470.1hypothetical protein-
N16961_RS16610426342..426713+372WP_001164080.1nucleotide pyrophosphohydrolase-
N16961_RS16615426780..427205+426WP_001882332.1DUF1778 domain-containing protein-
N16961_RS16620427202..427735+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--418911..419891980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T104258 WP_000221354.1 NZ_CP028828:422551-422838 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T104258 NZ_CP028828:422551-422838 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT104258 WP_001250179.1 NZ_CP028828:422310-422561 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT104258 NZ_CP028828:422310-422561 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References