Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 93210..93843 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag K6J77_RS14605 Protein ID WP_000843587.1
Coordinates 93210..93542 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J77_RS14610 Protein ID WP_000071008.1
Coordinates 93529..93843 (+) Length 105 a.a.

Genomic Context

K6J77_RS14550K6J77_RS14555K6J77_RS14560K6J77_RS14565K6J77_RS14570K6J77_RS14575K6J77_RS14580K6J77_RS14585K6J77_RS14590K6J77_RS14595K6J77_RS14600K6J77_RS14605K6J77_RS14610K6J77_RS14615K6J77_RS14620K6J77_RS14630K6J77_RS19080K6J77_RS19085K6J77_RS14640K6J77_RS19090K6J77_RS14645K6J77_RS14650K6J77_RS14655K6J77_RS14625
Location: 88645..88854 (210 bp)
Type: Others
Protein ID: WP_221277753.1
Location: 89111..89308 (198 bp)
Type: Others
Protein ID: WP_001894451.1
Location: 89668..89937 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 90273..90426 (154 bp)
Type: Others
Protein ID: Protein_166
Location: 90635..91021 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 91106..91465 (360 bp)
Type: Others
Protein ID: WP_226979446.1
Location: 91636..92013 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 92070..92184 (115 bp)
Type: Others
Protein ID: Protein_170
Location: 92193..92414 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 92580..92693 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 92642..92869 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 93210..93542 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 93529..93843 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 93980..94414 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 94582..94737 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 95910..96216 (307 bp)
Type: Others
Protein ID: Protein_179
Location: 96353..96751 (399 bp)
Type: Others
Protein ID: Protein_180
Location: 96875..97045 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 97045..97446 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 97449..97559 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 97634..98047 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 98261..98512 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 98502..98789 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 94862..95842 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1455088645..88854+210WP_221277753.1hypothetical protein-
K6J77_RS1455589111..89308+198WP_001894451.1DUF3709 domain-containing protein-
K6J77_RS1456089668..89937+270WP_001198131.1hypothetical protein-
K6J77_RS1456590273..90426+154Protein_166DUF645 family protein-
K6J77_RS1457090635..91021+387WP_000703163.1VOC family protein-
K6J77_RS1457591106..91465+360WP_226979446.1pullulanase-
K6J77_RS1458091636..92013+378WP_000411109.1hypothetical protein-
K6J77_RS1458592070..92184+115Protein_170acetyltransferase-
K6J77_RS1459092193..92414+222WP_032468461.1DUF1289 domain-containing protein-
K6J77_RS1459592580..92693+114WP_001889158.1hypothetical protein-
K6J77_RS1460092642..92869+228WP_073426587.1DUF1289 domain-containing protein-
K6J77_RS1460593210..93542+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1461093529..93843+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
K6J77_RS1461593980..94414+435WP_000256036.1GNAT family N-acetyltransferase-
K6J77_RS1462094582..94737+156WP_000751734.1hypothetical protein-
K6J77_RS1462594862..95842-981WP_000019370.1IS5-like element ISVch5 family transposase-
K6J77_RS1463095910..96216+307Protein_179CatB-related O-acetyltransferase-
K6J77_RS1908096353..96751+399Protein_180GNAT family N-acetyltransferase-
K6J77_RS1908596875..97045+171WP_001080654.1hypothetical protein-
K6J77_RS1464097045..97446+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
K6J77_RS1909097449..97559+111WP_082798255.1DUF3265 domain-containing protein-
K6J77_RS1464597634..98047+414WP_000049417.1VOC family protein-
K6J77_RS1465098261..98512+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J77_RS1465598502..98789+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670
flankIS/Tn--88179..88598419
flankIS/Tn--94862..95842980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T38625 WP_000843587.1 NZ_AP024548:93210-93542 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T38625 NZ_AP024548:93210-93542 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT38625 WP_000071008.1 NZ_AP024548:93529-93843 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT38625 NZ_AP024548:93529-93843 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References