38625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 93210..93843 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag K6J77_RS14605 Protein ID WP_000843587.1
Coordinates 93210..93542 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J77_RS14610 Protein ID WP_000071008.1
Coordinates 93529..93843 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14550 88645..88854 + 210 WP_221277753.1 hypothetical protein -
K6J77_RS14555 89111..89308 + 198 WP_001894451.1 DUF3709 domain-containing protein -
K6J77_RS14560 89668..89937 + 270 WP_001198131.1 hypothetical protein -
K6J77_RS14565 90273..90426 + 154 Protein_166 DUF645 family protein -
K6J77_RS14570 90635..91021 + 387 WP_000703163.1 VOC family protein -
K6J77_RS14575 91106..91465 + 360 WP_226979446.1 pullulanase -
K6J77_RS14580 91636..92013 + 378 WP_000411109.1 hypothetical protein -
K6J77_RS14585 92070..92184 + 115 Protein_170 acetyltransferase -
K6J77_RS14590 92193..92414 + 222 WP_032468461.1 DUF1289 domain-containing protein -
K6J77_RS14595 92580..92693 + 114 WP_001889158.1 hypothetical protein -
K6J77_RS14600 92642..92869 + 228 WP_073426587.1 DUF1289 domain-containing protein -
K6J77_RS14605 93210..93542 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14610 93529..93843 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
K6J77_RS14615 93980..94414 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J77_RS14620 94582..94737 + 156 WP_000751734.1 hypothetical protein -
K6J77_RS14625 94862..95842 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J77_RS14630 95910..96216 + 307 Protein_179 CatB-related O-acetyltransferase -
K6J77_RS19080 96353..96751 + 399 Protein_180 GNAT family N-acetyltransferase -
K6J77_RS19085 96875..97045 + 171 WP_001080654.1 hypothetical protein -
K6J77_RS14640 97045..97446 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K6J77_RS19090 97449..97559 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J77_RS14645 97634..98047 + 414 WP_000049417.1 VOC family protein -
K6J77_RS14650 98261..98512 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J77_RS14655 98502..98789 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670
flank IS/Tn - - 88179..88598 419
flank IS/Tn - - 94862..95842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T38625 WP_000843587.1 NZ_AP024548:93210-93542 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T38625 NZ_AP024548:93210-93542 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT38625 WP_000071008.1 NZ_AP024548:93529-93843 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT38625 NZ_AP024548:93529-93843 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References