Detailed information of TA system TA025707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 53083..53623
• Replicon: chromosome
• Accession: NC_016446
• Organism: Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A151JGK8
• Locus tag: HJ37_RS14285
• Protein ID: WP_000277238.1
• Coordinates: 53083..53352 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KML3
• Locus tag: HJ37_RS14290
• Protein ID: WP_001258569.1
• Coordinates: 53345..53623 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HJ37_RS14230	48089..48331	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HJ37_RS14235	48575..48961	+	387	WP_001015867.1	NUDIX hydrolase	-
HJ37_RS19360	49018..49131	+	114	WP_001900214.1	hypothetical protein	-
HJ37_RS14240	49140..49360	+	221	Protein_57	DUF1289 domain-containing protein	-
HJ37_RS14250	49618..50154	+	537	WP_000469482.1	GNAT family N-acetyltransferase	-
HJ37_RS14255	50291..50806	+	516	WP_001201509.1	lipocalin family protein	-
HJ37_RS14260	50956..51453	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
HJ37_RS14265	51450..51722	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
HJ37_RS19880	52115..52240	+	126	WP_001900195.1	DUF645 family protein	-
HJ37_RS19885	52256..52294	+	39	WP_106019118.1	hypothetical protein	-
HJ37_RS14280	52489..52935	+	447	WP_000006157.1	hypothetical protein	-
HJ37_RS14285	53083..53352	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HJ37_RS14290	53345..53623	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HJ37_RS19375	53952..54188	+	237	WP_161944222.1	DUF3709 domain-containing protein	-
HJ37_RS19895	54440..54646	+	207	Protein_68	DUF3709 domain-containing protein	-
HJ37_RS19900	54846..54947	+	102	WP_001921603.1	hypothetical protein	-
HJ37_RS14300	54937..55323	+	387	WP_000703163.1	VOC family protein	-
HJ37_RS14305	55518..55769	+	252	WP_001890111.1	TIGR03643 family protein	-
HJ37_RS19385	55742..55891	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
HJ37_RS14310	55983..56225	+	243	WP_000107461.1	hypothetical protein	-
HJ37_RS14315	56477..56755	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
HJ37_RS20205	57187..57307	+	121	Protein_75	DUF645 family protein	-
HJ37_RS19910	57326..57364	+	39	WP_082798268.1	hypothetical protein	-
HJ37_RS14325	57576..58043	+	468	WP_001289288.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	31115..136304	105189
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	catB9	-	36195..135928	99733

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10406.11 Da
• Isoelectric Point: 9.5084

>T25707 WP_000277238.1 NC_016446:c53352-53083 [Vibrio cholerae O1 str. 2010EL-1786]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T25707 NC_016446:c53352-53083 [Vibrio cholerae O1 str. 2010EL-1786]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10088.58 Da
• Isoelectric Point: 6.0728

>AT25707 WP_001258569.1 NC_016446:c53623-53345 [Vibrio cholerae O1 str. 2010EL-1786]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Nucleotide

• Length: 279 bp

>AT25707 NC_016446:c53623-53345 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Structures

Toxin

• AlphaFold DB: A0A151JGK8

Antitoxin

• AlphaFold DB: A0A151KTP9