Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 53083..53623 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HJ37_RS14285 Protein ID WP_000277238.1
Coordinates 53083..53352 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HJ37_RS14290 Protein ID WP_001258569.1
Coordinates 53345..53623 (-) Length 93 a.a.

Genomic Context

HJ37_RS14235HJ37_RS19360HJ37_RS14240HJ37_RS14250HJ37_RS14255HJ37_RS19880HJ37_RS19885HJ37_RS14280HJ37_RS19375HJ37_RS19895HJ37_RS19900HJ37_RS14300HJ37_RS14305HJ37_RS19385HJ37_RS14310HJ37_RS14315HJ37_RS20205HJ37_RS19910HJ37_RS14325HJ37_RS14230HJ37_RS14260HJ37_RS14265HJ37_RS14285HJ37_RS14290
Location: 48575..48961 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 49018..49131 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49140..49360 (221 bp)
Type: Others
Protein ID: Protein_57
Location: 49618..50154 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50291..50806 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52115..52240 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52256..52294 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52489..52935 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 53952..54188 (237 bp)
Type: Others
Protein ID: WP_161944222.1
Location: 54440..54646 (207 bp)
Type: Others
Protein ID: Protein_68
Location: 54846..54947 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 54937..55323 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 55518..55769 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 55742..55891 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 55983..56225 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 56477..56755 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 57187..57307 (121 bp)
Type: Others
Protein ID: Protein_75
Location: 57326..57364 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 57576..58043 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 48089..48331 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 50956..51453 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 51450..51722 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 53083..53352 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 53345..53623 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS1423048089..48331-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
HJ37_RS1423548575..48961+387WP_001015867.1NUDIX hydrolase-
HJ37_RS1936049018..49131+114WP_001900214.1hypothetical protein-
HJ37_RS1424049140..49360+221Protein_57DUF1289 domain-containing protein-
HJ37_RS1425049618..50154+537WP_000469482.1GNAT family N-acetyltransferase-
HJ37_RS1425550291..50806+516WP_001201509.1lipocalin family protein-
HJ37_RS1426050956..51453-498WP_000982260.1GNAT family N-acetyltransferase-
HJ37_RS1426551450..51722-273WP_000246253.1DUF1778 domain-containing protein-
HJ37_RS1988052115..52240+126WP_001900195.1DUF645 family protein-
HJ37_RS1988552256..52294+39WP_106019118.1hypothetical protein-
HJ37_RS1428052489..52935+447WP_000006157.1hypothetical protein-
HJ37_RS1428553083..53352-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
HJ37_RS1429053345..53623-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HJ37_RS1937553952..54188+237WP_161944222.1DUF3709 domain-containing protein-
HJ37_RS1989554440..54646+207Protein_68DUF3709 domain-containing protein-
HJ37_RS1990054846..54947+102WP_001921603.1hypothetical protein-
HJ37_RS1430054937..55323+387WP_000703163.1VOC family protein-
HJ37_RS1430555518..55769+252WP_001890111.1TIGR03643 family protein-
HJ37_RS1938555742..55891+150WP_071908333.1DUF3265 domain-containing protein-
HJ37_RS1431055983..56225+243WP_000107461.1hypothetical protein-
HJ37_RS1431556477..56755+279WP_000280324.1DUF3709 domain-containing protein-
HJ37_RS2020557187..57307+121Protein_75DUF645 family protein-
HJ37_RS1991057326..57364+39WP_082798268.1hypothetical protein-
HJ37_RS1432557576..58043+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T25707 WP_000277238.1 NC_016446:c53352-53083 [Vibrio cholerae O1 str. 2010EL-1786]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T25707 NC_016446:c53352-53083 [Vibrio cholerae O1 str. 2010EL-1786]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT25707 WP_001258569.1 NC_016446:c53623-53345 [Vibrio cholerae O1 str. 2010EL-1786]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT25707 NC_016446:c53623-53345 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References