Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 209443..209983 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag EEL44_RS01445 Protein ID WP_000277238.1
Coordinates 209714..209983 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag EEL44_RS01440 Protein ID WP_001258569.1
Coordinates 209443..209721 (+) Length 93 a.a.

Genomic Context

EEL44_RS01440EEL44_RS01445EEL44_RS01470EEL44_RS01475EEL44_RS01515EEL44_RS01375EEL44_RS20970EEL44_RS20975EEL44_RS01395EEL44_RS01400EEL44_RS01405EEL44_RS01410EEL44_RS01415EEL44_RS01420EEL44_RS01425EEL44_RS01430EEL44_RS01450EEL44_RS01460EEL44_RS01465EEL44_RS01480EEL44_RS01485EEL44_RS01500EEL44_RS01505EEL44_RS01510
Location: 209443..209721 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
Location: 209714..209983 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 211345..211617 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 211614..212111 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 214737..214979 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 205023..205490 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 205702..205740 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 205794..205937 (144 bp)
Type: Others
Protein ID: Protein_245
Location: 206312..206590 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 206842..207084 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 207176..207325 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 207298..207549 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 207744..208130 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 208120..208221 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 208421..208627 (207 bp)
Type: Others
Protein ID: Protein_252
Location: 208879..209157 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 210131..210577 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 210773..210811 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 210827..210952 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 212261..212776 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 212913..213449 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 213707..213988 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 213937..214050 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 214107..214493 (387 bp)
Type: Others
Protein ID: WP_001015867.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS01375205023..205490-468WP_001289288.1OsmC family protein-
EEL44_RS20970205702..205740-39WP_082798268.1hypothetical protein-
EEL44_RS20975205794..205937-144Protein_245DUF645 family protein-
EEL44_RS01395206312..206590-279WP_000280324.1DUF3709 domain-containing protein-
EEL44_RS01400206842..207084-243WP_000107461.1hypothetical protein-
EEL44_RS01405207176..207325-150WP_071908333.1DUF3265 domain-containing protein-
EEL44_RS01410207298..207549-252WP_001890111.1TIGR03643 family protein-
EEL44_RS01415207744..208130-387WP_000703163.1VOC family protein-
EEL44_RS01420208120..208221-102WP_001921603.1hypothetical protein-
EEL44_RS01425208421..208627-207Protein_252DUF3709 domain-containing protein-
EEL44_RS01430208879..209157-279WP_001921601.1DUF3709 domain-containing protein-
EEL44_RS01440209443..209721+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
EEL44_RS01445209714..209983+270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
EEL44_RS01450210131..210577-447WP_000006157.1hypothetical protein-
EEL44_RS01460210773..210811-39WP_106019118.1hypothetical protein-
EEL44_RS01465210827..210952-126WP_001900195.1DUF645 family protein-
EEL44_RS01470211345..211617+273WP_000246253.1DUF1778 domain-containing protein-
EEL44_RS01475211614..212111+498WP_000982260.1GNAT family N-acetyltransferase-
EEL44_RS01480212261..212776-516WP_001201509.1lipocalin family protein-
EEL44_RS01485212913..213449-537WP_000469482.1GNAT family N-acetyltransferase-
EEL44_RS01500213707..213988-282WP_001894429.1DUF1289 domain-containing protein-
EEL44_RS01505213937..214050-114WP_001900214.1hypothetical protein-
EEL44_RS01510214107..214493-387WP_001015867.1NUDIX hydrolase-
EEL44_RS01515214737..214979+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T113809 WP_000277238.1 NZ_CP033513:209714-209983 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T113809 NZ_CP033513:209714-209983 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT113809 WP_001258569.1 NZ_CP033513:209443-209721 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT113809 NZ_CP033513:209443-209721 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References