113809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 209443..209983 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag EEL44_RS01445 Protein ID WP_000277238.1
Coordinates 209714..209983 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag EEL44_RS01440 Protein ID WP_001258569.1
Coordinates 209443..209721 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01375 205023..205490 - 468 WP_001289288.1 OsmC family protein -
EEL44_RS20970 205702..205740 - 39 WP_082798268.1 hypothetical protein -
EEL44_RS20975 205794..205937 - 144 Protein_245 DUF645 family protein -
EEL44_RS01395 206312..206590 - 279 WP_000280324.1 DUF3709 domain-containing protein -
EEL44_RS01400 206842..207084 - 243 WP_000107461.1 hypothetical protein -
EEL44_RS01405 207176..207325 - 150 WP_071908333.1 DUF3265 domain-containing protein -
EEL44_RS01410 207298..207549 - 252 WP_001890111.1 TIGR03643 family protein -
EEL44_RS01415 207744..208130 - 387 WP_000703163.1 VOC family protein -
EEL44_RS01420 208120..208221 - 102 WP_001921603.1 hypothetical protein -
EEL44_RS01425 208421..208627 - 207 Protein_252 DUF3709 domain-containing protein -
EEL44_RS01430 208879..209157 - 279 WP_001921601.1 DUF3709 domain-containing protein -
EEL44_RS01440 209443..209721 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EEL44_RS01445 209714..209983 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
EEL44_RS01450 210131..210577 - 447 WP_000006157.1 hypothetical protein -
EEL44_RS01460 210773..210811 - 39 WP_106019118.1 hypothetical protein -
EEL44_RS01465 210827..210952 - 126 WP_001900195.1 DUF645 family protein -
EEL44_RS01470 211345..211617 + 273 WP_000246253.1 DUF1778 domain-containing protein -
EEL44_RS01475 211614..212111 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
EEL44_RS01480 212261..212776 - 516 WP_001201509.1 lipocalin family protein -
EEL44_RS01485 212913..213449 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
EEL44_RS01500 213707..213988 - 282 WP_001894429.1 DUF1289 domain-containing protein -
EEL44_RS01505 213937..214050 - 114 WP_001900214.1 hypothetical protein -
EEL44_RS01510 214107..214493 - 387 WP_001015867.1 NUDIX hydrolase -
EEL44_RS01515 214737..214979 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T113809 WP_000277238.1 NZ_CP033513:209714-209983 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T113809 NZ_CP033513:209714-209983 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT113809 WP_001258569.1 NZ_CP033513:209443-209721 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT113809 NZ_CP033513:209443-209721 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References