56910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324478..325244 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag AN947_RS01535 Protein ID WP_000982260.1
Coordinates 324478..324975 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag AN947_RS01540 Protein ID WP_000246253.1
Coordinates 324972..325244 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS01480 319920..320624 + 705 WP_000087610.1 HNH endonuclease -
AN947_RS01485 320782..321120 + 339 WP_000713853.1 hypothetical protein -
AN947_RS01490 321274..321591 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
AN947_RS01495 321610..321852 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AN947_RS01500 322096..322482 + 387 WP_001015867.1 NUDIX hydrolase -
AN947_RS01505 322539..322652 + 114 WP_001900214.1 hypothetical protein -
AN947_RS01510 322601..322882 + 282 WP_001894429.1 DUF1289 domain-containing protein -
AN947_RS01520 323140..323676 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
AN947_RS01525 323813..324328 + 516 WP_001201509.1 lipocalin family protein -
AN947_RS01535 324478..324975 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
AN947_RS01540 324972..325244 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
AN947_RS01550 325637..325762 + 126 WP_001900195.1 DUF645 family protein -
AN947_RS20715 325778..325816 + 39 WP_106019118.1 hypothetical protein -
AN947_RS01560 326012..326458 + 447 WP_000006157.1 hypothetical protein -
AN947_RS01570 326606..326875 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
AN947_RS01575 326868..327146 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AN947_RS01585 327432..327710 + 279 WP_001921601.1 DUF3709 domain-containing protein -
AN947_RS20720 327962..328168 + 207 Protein_290 DUF3709 domain-containing protein -
AN947_RS20725 328368..328469 + 102 WP_001921603.1 hypothetical protein -
AN947_RS01590 328459..328845 + 387 WP_000703163.1 VOC family protein -
AN947_RS01595 329040..329291 + 252 WP_001890111.1 TIGR03643 family protein -
AN947_RS01600 329264..329413 + 150 WP_071908333.1 DUF3265 domain-containing protein -
AN947_RS01605 329505..329747 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T56910 WP_000982260.1 NZ_CP012666:c324975-324478 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T56910 NZ_CP012666:c324975-324478 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT56910 WP_000246253.1 NZ_CP012666:c325244-324972 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT56910 NZ_CP012666:c325244-324972 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References