198990

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422199..422965 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag J9265_RS16040 Protein ID WP_000982260.1
Coordinates 422199..422696 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag J9265_RS16045 Protein ID WP_000246253.1
Coordinates 422693..422965 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15995 (J9265_15995) 418061..418367 + 307 Protein_471 CatB-related O-acetyltransferase -
J9265_RS19165 418504..418902 + 399 Protein_472 GNAT family N-acetyltransferase -
J9265_RS19170 419026..419196 + 171 WP_001080654.1 hypothetical protein -
J9265_RS16005 (J9265_16005) 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
J9265_RS16010 (J9265_16010) 419600..419710 + 111 WP_082798255.1 DUF3265 domain-containing protein -
J9265_RS16015 (J9265_16015) 419785..420198 + 414 WP_000049417.1 VOC family protein -
J9265_RS16020 (J9265_16020) 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16025 (J9265_16025) 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS16030 (J9265_16030) 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
J9265_RS19175 421580..421702 + 123 Protein_480 acetyltransferase -
J9265_RS16035 (J9265_16035) 421873..421997 + 125 Protein_481 DUF645 family protein -
J9265_RS19180 422114..422182 + 69 Protein_482 acetyltransferase -
J9265_RS16040 (J9265_16040) 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
J9265_RS16045 (J9265_16045) 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
J9265_RS19185 423117..423179 + 63 Protein_485 acetyltransferase -
J9265_RS16050 (J9265_16050) 423196..423864 + 669 WP_000043871.1 hypothetical protein -
J9265_RS16055 (J9265_16055) 424016..424303 + 288 WP_000426470.1 hypothetical protein -
J9265_RS16060 (J9265_16060) 424444..424815 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
J9265_RS19190 425038..425307 + 270 WP_000179600.1 DUF1778 domain-containing protein -
J9265_RS16070 (J9265_16070) 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
J9265_RS19195 425847..425957 + 111 WP_086010065.1 DUF3265 domain-containing protein -
J9265_RS16075 (J9265_16075) 426039..426296 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16080 (J9265_16080) 426284..426586 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS16085 (J9265_16085) 426820..427737 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T198990 WP_000982260.1 NZ_CP072848:c422696-422199 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T198990 NZ_CP097082:352700-353047 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT198990 WP_000246253.1 NZ_CP072848:c422965-422693 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT198990 NZ_CP097082:353047-353346 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References